Results 301 to 310 of about 88,625 (333)
Some of the next articles are maybe not open access.
Aspirin resistance and other aspirin-related concerns
Neurological Sciences, 2015Aspirin is a widely used medication and has become a cornerstone for treating cardiovascular disease. Aspirin can significantly reduce the incidence of cardiovascular ischemic events, recurrence and mortality, thereby improving the long-term prognosis of patients.
Weijun Zhou +5 more
openaire +3 more sources
Aspirin Resistance: Does It Exist?
Seminars in Thrombosis and Hemostasis, 2007Aspirin irreversibly inhibits platelet cyclooxygenase-1 (COX-1). Aspirin sensitivity can be measured easily by its inhibition of arachidonic acid (AA) -induced platelet aggregation. Aspirin resistance has to be defined by its inability to inhibit COX-1. By using this definition, aspirin resistance very likely does not exist. A specific rapid laboratory
Rao, Gundu H.R., Michiels, Jan J.
openaire +4 more sources
Aspirin and aspirin resistance in coronary artery disease
Current Opinion in Pharmacology, 2013Aspirin is still the mainstay of antiplatelet therapy in the secondary prevention of coronary artery disease. However certain patients do not benefit from the antithrombotic effects of aspirin. The phenomenon of so-called aspirin resistance can be considered from the clinical and laboratory perspective.
Gregory Y.H. Lip +2 more
openaire +3 more sources
Possible Mechanisms of Aspirin Resistance
Journal of Thrombosis and Thrombolysis, 2002Data regarding possible mechanisms of aspirin (ASA) resistance in patients with recurrent myocardial infarction (MI) or vascular ischemia are limited. Five major possible mechanisms of ASA resistance are documented in the primary literature and are discussed in this paper.
Pritesh J. Gandhi +1 more
openaire +3 more sources
Aspirin Resistance and Genetic Polymorphisms
Journal of Thrombosis and Thrombolysis, 2002Differences in genetic makeup or polymorphisms can affect individual drug response. Detecting genetic variation may help predict how a patient will respond to a drug and could be used as a tool to select optimal therapy, tailor dosage regimens, and improve clinical outcomes. The data are replete relative to the therapeutic efficacy of aspirin (ASA) for
Pritesh J. Gandhi +1 more
openaire +3 more sources
Aspirin resistance: Truth or dare
Pharmacology & Therapeutics, 2006Acetylsalicylic acid, or aspirin (ASA), is widely used in patients with cardiovascular disease to prevent acute ischemic events. However, platelet response to ASA is not equal in all individuals, and a high variability in the prevalence of ASA resistance is reported in the literature (0.4-83%).
Jean G. Diodati +3 more
openaire +3 more sources
Journal of Stroke Medicine, 2018
Stroke is a leading cause of death and disability worldwide. Aspirin is the most commonly used antiplatelet drug in both primary and secondary prevention of cerebrovascular and cardiovascular diseases. A proportion of patients may have stroke recurrence while they are on treatment with aspirin, giving rise to term aspirin resistance or aspirin failure.
Rohit Bhatia, Pranjal Sisodia
openaire +2 more sources
Stroke is a leading cause of death and disability worldwide. Aspirin is the most commonly used antiplatelet drug in both primary and secondary prevention of cerebrovascular and cardiovascular diseases. A proportion of patients may have stroke recurrence while they are on treatment with aspirin, giving rise to term aspirin resistance or aspirin failure.
Rohit Bhatia, Pranjal Sisodia
openaire +2 more sources
Diagnostics for Aspirin Resistance
Molecular Diagnosis & Therapy, 2008Udaya S. Tantry +2 more
openaire +3 more sources