Results 71 to 80 of about 47,972 (292)

Resistance to aspirin and clopidogrel therapy [PDF]

International Journal of Laboratory Hematology, 2010
SummaryIntroduction:  Despite increasing evidence on the roles of aspirin and clopidogrel in decreasing morbidity and mortality from cardiovascular disease, resistance to therapy remains an emerging clinical entity. The aim of this review was to revisit current knowledge of the mechanisms, laboratory evaluation, clinical impact and management of ...
J. Beresian, Khaled M. Musallam, S. Assaad, Samir Alam, Maurice Khoury, A. Bitar, Khalil M. Charafeddine, Ali T. Taher   +7 more
openaire   +3 more sources

Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation

Advanced Functional Materials, EarlyView.
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao, Maoze Wang, Jinling Huang, Yu Wang, Jing Zhao, Ran Wang, Zhi Ping Xu, Jianping Jiang, Lingxiao Zhang   +8 more
wiley   +1 more source

Antiplatelet Resistance: A Review of Concepts, Mechanisms, and Implications for Management in Acute Ischemic Stroke and Transient Ischemic Attack

Stroke: Vascular and Interventional Neurology, 2023
Acute ischemic stroke is a leading cause of death and major disability worldwide. Approximately 50% of ischemic strokes are caused by atherothrombotic occlusion of the cerebral arteries, and antiplatelets are the mainstay of secondary stroke preventative
Kailash Krishnan, Thanh N. Nguyen, Jason P. Appleton, Zhe Kang Law, Mark Caulfied, Claudia P. Cabrera, Rob Lenthall, David Hewson, Timothy England, Norman McConachie, Permesh Dhillon, Luqman Malik, Anna Podlasek, Craig J. Smith, Jesse Dawson, Thompson G. Robinson, Nikola Sprigg, Martin A. James, Phil White, Michael J.R. Desborough, Joannes Hermans, Philip M. Bath   +21 more
doaj   +1 more source

A contemporary viewpoint on ‘aspirin resistance’ [PDF]

Annals of Medicine, 2012
Aspirin is an irreversible inhibitor of platelet prostaglandin synthase activity, and is the most widely prescribed drug for the secondary prevention of cardiovascular disease. In recent years, clinical and laboratory evidence has shown significant individual variability in the response to aspirin and its link to clinical outcome.
Eduard Shantsila, Andrew D. Blann, Nadzeya Kuzniatsova, Gregory Y.H. Lip   +3 more
openaire   +2 more sources

Supervariate Gel Transforms into Various Biominerals in Salt Solutions

Advanced Functional Materials, EarlyView.
It is revealed that common calcium‐based biominerals can form from a stable, non‐toxic ‘supervariate’ gel. This tunable gel selectively yields calcite or hydroxyapatite in carbonate/phosphate solutions, while CaCl₂ facilitates the formation of dihydrate calcium pyrophosphate, which converts to hydroxyapatite upon drying. These findings provide insights
Xinxue Tang, Chong Wang, Yuk‐Tong Cheng, Junda Shen, Yunchen Long, Hongkun Li, Jie Yan, Yang Ren, Xiao Ma, Yufeng Huang, Zhengtao Xu, Jian Lu, Yang Yang Li   +12 more
wiley   +1 more source

ASPIRIN RESISTANCE AS A RISK MARKER FOR VENOUS THROMBOEMBOLIC COMPLICATIONS

Атеросклероз, 2018
The possible mechanisms for the development of aspirin resistance, platelet involvement in thrombus formation, inflammation and atherogenesisare presented.
M. V. Kruchinina, A. A. Gromov, A. V. Rabko, P. A. Abdullaeva, V. A. Baum, V. M. Generalov, K. V. Generalov, V. N. Kruchinin, S. V. Rykhlitskiy, G. V. Shuvalov   +9 more
doaj   +1 more source

Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer : a systematic review and overview of reviews [PDF]

, 2013
Background: Prophylactic aspirin has been considered to be beneficial in reducing the risks of heart disease and cancer. However, potential benefits must be balanced against the possible harm from side effects, such as bleeding and gastrointestinal (GI ...
Clarke, Aileen, Connock, M., Freeman, Karoline, Grove, Amy L., Gurung, B., Gurung, T., Johnson, Samantha Ann, Kandala, Ngianga-Bakwin, Morrow, S., Sutcliffe, P. (Paul)   +9 more
core   +1 more source

Aspirin Resistance and Atherothrombotic Disease

Journal of the American College of Cardiology, 2005
Acute coronary syndromes and other manifestations of atherothrombotic disease are primarily caused by atherosclerotic plaque rupture or fissuring and subsequent occlusive or subocclusive thrombus formation. Platelets play a critical role in the pathophysiology of atherothrombotic disease, and aspirin is the most commonly used antiplatelet agent ...
Peter J. Mason, Jane E. Freedman, Alice K. Jacobs   +2 more
openaire   +3 more sources

Accelerated Discovery of High‐Performance PCFC Cathodes: Computational‐Experimental Optimization of Cobalt‐Substituted Ba0.95La0.05FeO3‐δ

Advanced Functional Materials, EarlyView.
An integrated computational–experimental strategy accelerates the discovery of high‐performance PCFC cathodes. Computational screening using machine learning interatomic potentials and targeted experiments identifies optimal cobalt substitution in Ba0.95La0.05FeO3‐δ, reducing area‐specific resistance by 58% at 500 °C.
Abdullah Tahir, Yuhao Wang, Jingwei Li, Yunfeng Tian, Francesco Ciucci   +4 more
wiley   +1 more source

The association between aspirin resistance and extent and severity of coronary atherosclerosis

İstanbul Kuzey Klinikleri, 2018
INTRODUCTION[|]Uncontrolled inflammatory responses could contribute to the pathogenesis of many leading causes of human morbidity and mortality. Aspirin is an anti-inflammatory and antithrombotic drug that is used in the primary and secondary protection ...
Serkan Kahraman, Ali Dogan, Murat Ziyrek, Emrah Usta, Onder Demiroz, Cavlan Ciftci   +5 more
doaj   +1 more source