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Case Report: The effect of asplenia on the response to influenza vaccination and passive transfer of immunity in an adult female pig [PDF]

Frontiers in Immunology
Asplenia is an important cause of morbidity and mortality in humans. However, there are only very rare examples of this condition reported in domesticated species. Here we present a case of asplenia, diagnosed at necropsy, in a crossbred adult female pig
Michael C. Rahe, John J. Byrne, Danielle Meritet, Erika Gruber, Stephanie N. Langel, Elisa Crisci   +5 more
doaj   +2 more sources

Assessing the Vulnerability of Splenectomized Patients to Severe COVID-19 Outcomes: A Systematic Review and Meta-Analysis [PDF]

Vaccines
Background: Splenectomized/asplenic individuals are at a heightened risk for severe infections due to compromised immune function. However, the impact of splenectomy/asplenia on COVID-19 outcomes remains underexplored.
Francesco Paolo Bianchi, Massimo Giotta, Andrea Martinelli, Maria Grazia Giurgola, Giulia Del Matto, Elita Mastrovito, Maria Tina Fedele, Giuseppe Manca, Salvatore Minniti, Maurizio De Nuccio, Vincenzo Gigantelli, Silvio Tafuri, Stefano Termite   +12 more
doaj   +2 more sources

Case Report: Rethinking pulmonary arterial hypertension: immune and metabolic adaptations in a 34-year case of insidious progression [PDF]

Frontiers in Cardiovascular Medicine
BackgroundPulmonary arterial hypertension (PAH) is traditionally characterized as a rapidly progressive, fatal disease. Yet increasing evidence suggests that immune dysregulation, endothelial injury, and metabolic adaptation can sustain subclinical ...
Bronwen Erickson-Keith
doaj   +2 more sources

From multiple spleens to absence: Insights from two cases of heterotaxy syndromes [PDF]

Radiology Case Reports
Heterotaxy syndrome is a rare congenital disorder characterized by abnormal arrangement of the thoracic and abdominal organs and is classified into polysplenia (left isomerism) and asplenia (right isomerism) syndromes.
Suman Paudel, MD, Rishi Ram Banjade, MBBS, Niraj Kumar Sharma, MD, Sharmila Ghimire, MD, Prerana Singh Rokaha, MBBS   +4 more
doaj   +2 more sources

Vaccinations in Pediatric Hematology and Oncology: Biologic Basis, Clinical Applications, and Perspectives [PDF]

Vaccines
Children with hemato-oncological diseases represent a heterogeneous population at heightened risk for vaccine-preventable diseases. Their immunosuppressed state reduces vaccine efficacy and raises safety concerns regarding live attenuated vaccines due to
Baldassarre Martire, Alessandra Beni, Maria Felicia Mastrototaro, Veronica Santilli, Giorgio Ottaviano, Davide Montin, Caterina Rizzo, Mayla Sgrulletti, Michele Miraglia del Giudice, Giorgio Costagliola, Viviana Moschese   +10 more
doaj   +2 more sources

Autosplenectomy in a Patient With Autoimmune Polyglandular Syndrome Type 2 (APS-2) [PDF]

Case Reports in Endocrinology
Autoimmune glandular syndrome type 2 is a complex genetic condition where a triad of endocrinopathies is involved, namely, Addison’s disease, type 1 diabetes, and/or autoimmune thyroid disorder.
Luqman S. Fauzi, Airin Jyoty, Yashwin Sredharan, Manohara Kenchaiah   +3 more
doaj   +2 more sources

Asplenia in left isomerism

Annals of Pediatric Cardiology
Anatomical configurations where the viscero-atrial structures do not follow the usual arrangement or mirror-imaged arrangement is described conventionally as heterotaxy.
Usnish Adhikari, Venkatesh Gurajala, Palanisamy Dinesh Raja, Anoop Ayyappan, Deepti Narasimhaiah, Arun Gopalakrishnan   +5 more
doaj   +3 more sources

Asplenia Syndrome in a Neonate: A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2016
Asplenia syndrome is a syndrome of right isomerism or attempted bilateral right sidedness. It includes congenital asplenia in association with complex congenital cyanotic heart disease and situs anomalies of the other thoracoabdominal organs.
Kapil Bhalla, Jasbir Singh, Jaivinder Yadav, Suchi Mehra   +3 more
doaj   +1 more source

Asplenia and Fever [PDF]

Baylor University Medical Center Proceedings, 2015
A 45-year-old-man presented with the abrupt onset of a fever over 30 years after surgical splenectomy. He presented with symptoms and findings that seemed consistent with influenza. He rapidly developed fulminant meningitis that resulted in his death.
Mitchell L, Huebner, Kristin A, Milota
openaire   +2 more sources

The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism

Frontiers in Physiology, 2022
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia, and progressive organ failure.
Sari Peretz, Sari Peretz, Leonid Livshits, Leonid Livshits, Etheresia Pretorius, Asya Makhro, Anna Bogdanova, Anna Bogdanova, Max Gassmann, Ariel Koren, Carina Levin, Carina Levin   +11 more
doaj   +1 more source