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Asplenia and spleen hypofunction

Nature Reviews Disease Primers, 2022
Asplenia (the congenital or acquired absence of the spleen) and hyposplenism (defective spleen function) are common causes of morbidity and mortality. The spleen is a secondary lymphoid organ that is responsible for the regulation of immune responses and blood filtration.
Marco Vincenzo Lenti, Sarah Luu, Rita Carsetti, Faith Osier, Rodney Ogwang, Obiageli E. Nnodu, Ursula Wiedermann, Jo Spencer, Franco Locatelli, Gino Roberto Corazza, Antonio Di Sabatino   +10 more
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Asplenia and Hyposplenism

Immunology and Allergy Clinics of North America, 2020
Jacqueline D. Squire, Mandel Sher
exaly   +2 more sources

Spleen Australia guidelines for the prevention of sepsis in patients with asplenia and hyposplenism in Australia and New Zealand [PDF]

Internal Medicine Journal, 2017
People with asplenia/hyposplenism are at increased risk of fulminant sepsis, which carries a high mortality rate. A range of preventive measures is recommended although there is ongoing evidence that knowledge of and adherence to these strategies is poor.
Kudzai Kanhutu, Penelope Jones, Allen C Cheng   +2 more
exaly   +3 more sources

Sepsis and congenital asplenia

The Journal of Pediatrics, 1977
Fifty-nine children with congenital asplenia were reviewed for episodes of severe infection. Seven children had isolated asplenia and 52 had asplenia associated with complex congenital heart disease (asplenia syndrome). A control group of eusplenic children with comparable cardiac lesions were assembled and used for comparative statistical analysis ...
J D, Waldman, A, Rosenthal, A L, Smith, S, Shurin, A S, Nadas   +4 more
openaire   +2 more sources

ASPLENIA AND POLYSPLENIA SYNDROME

Acta Pathologica Japonica, 1982
This report described the morphological characteristics of seven cases of asplenia syndrome and three of polysplenia syndrome. Each syndrome has been characterized by a tendency for symmetric development of normally asymmetric organs, with varying degrees of cardiovascular anomalies.
Y, Shinohara, S, Komiya, A, Nakashima, T, Nakashima, S, Takeuchi, E, Ono, S, Yukizane, C, Tanaka, T, Matsuishi, T, Koga, Y, Hieda, H, Nakashima, A, Ichikawa   +12 more
openaire   +2 more sources

Congenital asplenia study: clinical and laboratory characterisation of adults with congenital asplenia

Annals of Hematology, 2022
Congenital asplenia is a rare disorder commonly associated with other visceral and cardiac congenital anomalies. Isolated congenital asplenia is even less common than syndromic forms. The risk of severe bacterial infections associated with asplenia is the most concerning clinical implication and carries a significant mortality risk.
Grace I, Butel-Simoes, Penelope, Jones, Erica M, Wood, Denis, Spelman, Ian J, Woolley, Samar, Ojaimi   +5 more
openaire   +2 more sources

The absent and vanishing spleen: Congenital asplenia and hyposplenism-two case reports

Acta Paediatrica, International Journal of Paediatrics, 2005
Contains fulltext : 48194.pdf (Publisher’s version ) (Closed access)Two unrelated patients are reported: one with isolated familial asplenia diagnosed postmortem, the other with isolated hyposplenism diagnosed after recurring invasive ...
Deuren, M. van, Halbertsma, F.J., Weemaes, C.M.R., Neeleman, C.   +3 more
exaly   +2 more sources

Asplenia congenita

Medico e Bambino pagine elettroniche, 2020
The paper presents a case of congenital asplenia diagnosed occasionally in a child who previously presented with a pneumococcal sepsis. The case offers the opportunity to discuss about the elevated risk of severe invasive infections in patients with congenital asplenia and the importance of early diagnosis so to prevent infections by starting an ...
Migliarino, Vanessa, Lapenna, Roberta, Comici, Alberto, Miani, Maria Paola, Naviglio, Samuele, Barbi, Egidio   +5 more
openaire   +1 more source

The Concept of Functional Asplenia

New England Journal of Medicine, 1969
Removal of the normal spleen (for example, after trauma or during abdominal operations on adjacent structures) is often followed by the appearance of abnormal red cells in the peripheral blood. In certain hematologic disorders in which the spleen is enlarged and is believed to be hyperactive, splenectomy can result in a strikingly bizarre blood smear ...
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Asplenia and Polysplenia

Journal of Diagnostic Medical Sonography, 1991
Abdominal sonograms on seven patients with asplenia syndrome and six patients with polysplenia syndrome were retrospectively reviewed. All seven patients with asplenia had a horizontal symmetric configuration of the liver, and three patients had the cardiac apex opposite the stomach.
Raksha K. Patel, Glenn A. Rouse, Phil-Ann Tan-Sinn   +2 more
openaire   +1 more source