Results 101 to 110 of about 634,315 (303)

Defects Can Increase the Melting Temperature of DNA-Nanoparticle Assemblies

, 2007
DNA-gold nanoparticle assemblies have shown promise as an alternative technology to DNA microarrays for DNA detection and RNA profiling. Understanding the effect of DNA sequences on the melting temperature of the system is central to developing reliable ...
Harris, Nolan C., Kiang, Ching-Hwa
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Double window viewing chamber assembly [PDF]

, 1986
A viewing chamber which permits observation of a sample retained therein includes a pair of double window assemblies mounted in opposed openings in the walls thereof so that a light beam can directly enter and exit from the chamber.
Elkins, B. R., Keller, V. W., Owen, R. B., White, W. T.   +3 more
core   +1 more source

Waterproofed Photomultiplier Tube Assemblies for the Daya Bay Reactor Neutrino Experiment

, 2015
In the Daya Bay Reactor Neutrino Experiment 960 20-cm-diameter waterproof photomultiplier tubes are used to instrument three water pools as Cherenkov detectors for detecting cosmic-ray muons.
Chow, Ken, Cummings, John, Edwards, Emily, Edwards, William, Ely, Ry, Hoff, Matthew, Lebanowski, Logan, Li, Bo, Li, Piyi, Lin, Shih-Kai, Liu, Dawei, Liu, Jinchang, Luk, Kam-Biu, Miao, Jiayuan, Napolitano, Jim, Ochoa-Ricoux, Juan Pedro, Peng, Jen-Chieh, Qi, Ming, Steiner, Herbert, Stoler, Paul, Stuart, Mary, Wang, Lingyu, Yang, Changgen, Zhong, Weili   +23 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Acentric langmuir-blodgett: film assemblies [PDF]

, 1985
In recent years there has been considerable interest In the use of Langmuir-Blodgett (LB) films as the basis of active and passive thin film devices. One such application is in room temperature, pyroelectric thermal imaging systems.
Christie, P
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Freedom of peaceful assembly and children: law and practice of Russia and Germany

Антиномии, 2018
This article provides the comparative constitutional research of the Public Assembly Law in Germany and Russia. In particular, the author examines constitutionality and permissibility of children’s participation in public assemblies.
Alexander V. Salenko
doaj   +1 more source

The 8.4-GHz low-noise maser pump source assembly [PDF]

Improved pump source assemblies and new 8.4-GHz low noise traveling-wave masers (TWMs) were installed at the same time at Deep Space Stations 14 and 43 as part of the Mark IVA DSCC Antenna Microwave Subsystems upgrade. The pump source assemblies are part
Cardenas, R.
core   +1 more source