Results 111 to 120 of about 312,451 (313)
, 2020 We introduce and analyze the concept of an assembly map from the original homotopy theoretic point of view. We give also interpretations in terms of surgery theory, controlled topology and index theory. The motivation is that prominent conjectures of Farrell-Jones and Baum-Connes about K- and L-theory of group rings and group C^*-algebras predict that ...
openaire +2 more sources
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Governing permanent citizens’ assemblies in Belgium
All over the world, initiatives to institutionalize deliberative democracy, particularly in the form of citizens’ assemblies, are springing up. Belgium, a small country in the heart of Europe, is probably one of the leading laboratories of this ...
Governing Citizens Assemblies +1 more
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Revised constitution and bylaws of the Pentecostal Assemblies of Newfoundland and Labrador
, 1966 Revised Constitution and Bylaws of the Pentecostal Assemblies of Newfoundland and Labrador June,1966Preamble -- Name: Article I -- Nature: Article II -- Prerogatives: Article III -- Principles: Article IV -- Statement of fundamental truths: Article V ...
Pentecostal Assemblies of Newfoundland
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, 2017 The 8 nm diameter cavity endows the ferritin cage with a natural space to encapsulate food components. In this work, urea was explored as a novel medium to facilitate the formation of ferritin–polyphenol co-assemblies. Results indicated that urea (20 mM)
Demei Meng (3742762) +5 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
, 2018 Assemblies and sequence data for avian haemosporidians. The 'assemblies' directory contains the contigs from the last iteration of aTRAM 2.0 assemblies for all individuals processed.
Barrow, Lisa +9 more
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source