Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Title from caption of PDF document (viewed Jan. 26, 2006).; "This Members Only Brief is an update of an earlier Brief on this subject dated June 12, 1996 (Volume 121 Issue 16)."; "October 4, 2004."; Harvested from the web on 1/26/06This Members Only ...
Mullin, Phil.
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Decision on the Date and Venue of the 23rd Ordinary Session of the Assembly of The African Union [PDF]
Twenty- Third Ordinary Session of the Assembly of the Union in ...
The Assembly
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Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
This book contains reports from the national officers and program directors of The Links, Inc., about the activities of the national level of the organization from 1982-1984. It was presented to the 24th National Assembly.
Links, Inc. National Assembly.
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Decision on the Transformation of the African Union Commission into the African Union Authority Doc. Assembly/Au/13(Xviii) [PDF]
Progress Report of the Commission on the implementation of Decision Assembly/AU/Dec.372 ...
The Assembly
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YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Decision on the Progress Report of the Commission on the Implementation of Decision Assembly/Au/Dec.270(Xiv) on the Second Ministerial Meeting On The Rome Statute Of The International Criminal Court (Icc) Doc. Assembly/Au/10(Xv) [PDF]
Progress Report of the Commission on the Implementation of Decision Assembly/AU/Dec.270 ...
The Assembly
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Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Decision on Boosting Intra-African trade and Fast Tracking the Continental Free Trade Area Doc. Assembly/Au/11(Xix) [PDF]
Decision Assembly/AU/Dec.394(XVIII) taken on 30th January 2012 at its Eighteenth Ordinary ...
The Assembly
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