Results 41 to 50 of about 3,971,277 (297)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Spatio-temporal relays control layer identity of direction-selective neuron subtypes in Drosophila
Nature Communications, 2018 Direction-selective T4/T5 neurons show layer-specific projections in the fly visual circuit. Examining the mechanisms behind their development, the authors found that a relay of Wnt and Bmp signaling across neuroepithelial domains and transcription ...
Holger Apitz, Iris Salecker
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Multi-objective topology optimization and structural analysis of periodic spaceframe structures
Materials & Design, 2020 Reduction of structural weight provides significant benefits in many engineering applications. While methods to optimise structural shape and topology of both continuous solids and discrete frame structures have existed for a while, the advent of ...
Jarad Lim, Chao You, Iman Dayyani
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N-Dopant-Mediated Growth of Metal Oxide Nanoparticles on Carbon Nanotubes
Nanomaterials, 2021 Metal oxide nanoparticles supported on heteroatom-doped graphitic surfaces have been pursued for several decades for a wide spectrum of applications. Despite extensive research on functional metal oxide nanoparticle/doped carbon nanomaterial hybrids, the
Jin Ah Lee +3 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
MATEC Web of Conferences, 2016 Today’s production companies are challenged with: the assembly of different product variants with lot size of one on a single assembly line and the increase of product variants.
Müller Rainer +4 more
doaj +1 more source
A Product Development Approach in The Field of Micro-Assembly with Emphasis on Conceptual Design
Applied Sciences, 2019 Faster product lifecycles make long-term investments in machines for micro assembly riskier. Therefore, reconfigurable manufacturing systems gain more and more attention.
Christoph Gielisch +3 more
doaj +1 more source
A 24 hour naproxen dose on gastrointestinal distress and performance during cycling in the heat
Sports Medicine and Health Science, 2020 Using a double-blind, randomized and counterbalanced, cross-over design, we assessed naproxen's effects on gastrointestinal (GI) distress and performance in eleven volunteers (6 male, 5 female). Participants completed 4 trials: 1) placebo and ambient); 2)
Dawn M. Emerson +7 more
doaj +1 more source
Investigation of Parameters of Fused Deposition Modelling 3D Prints with Compression Properties
Advances in Materials Science and Engineering, 2022 Three-dimensional (3D) printing has been attracting a great deal of attention in recent years in many application fields, for example, in the aerospace, construction, industry, art, education, protection, security, and medical fields.
Dereje Berihun Sitotaw +3 more
doaj +1 more source