Results 61 to 70 of about 7,311 (216)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Rare microbial taxa as the major drivers of nutrient acquisition under moss biocrusts in karst area

Frontiers in Microbiology
Karst rocky desertification refers to the process of land degradation caused by various factors such as climate change and human activities including deforestation and agriculture on a fragile karst substrate. Nutrient limitation is common in karst areas.
Xintong Dong, Man Chen, Qi Chen, Kangfei Liu, Jie Long, Yunzhou Li, Yinuo Ren, Tao Yang, Jinxing Zhou, Saman Herath, Xiawei Peng, Xiawei Peng, Xiawei Peng   +12 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Soil bacteria community characteristics and their regulatory mechanisms on greenhouse gas emissions in island forests of the Sanjiang Plain

Frontiers in Ecology and Evolution
This study focused on four typical island forest types (Populus davidiana, Betula platyphylla, Quercus mongolica, and mixed forest) in the Sanjiang Plain to investigate the differences in soil physicochemical properties and bacterial community ...
Jin-Bo Li, Yu Zhang, Yu-Tong Ma, Zhao-Dong Cui, Nan Xu, Hai-Xiu Zhong   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Root Microbiome Assembly Underpins the Ecological Role of Emergent Macrophytes in a Pilot-Scale Constructed Wetland

Biology
Constructed wetlands (CWs) depend on plant–microbe associations for pollutant transformation, yet the processes linking macrophyte identity to rhizosphere microbiome assembly remain insufficiently resolved.
July Z. Florez, Lourdes Varela-Prieto, Ana Zárate, Aracelly Caselles-Osorio, Alejandro Llanos-Lizcano, Pablo Bruna   +5 more
doaj   +1 more source

A study on development of a work instruction system for assembly cells based on analysis of learning processes

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2014
A cellular manufacturing system is a kind of lean and flexible manufacturing systems in which a worker or a group of workers carry out all assembly processes of a product.
Yoshitaka TANIMIZU, Satoru ISHII, Takashi YOKOTANI   +2 more
doaj   +1 more source