Results 71 to 80 of about 7,311 (216)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Vertical dynamic patterns of Vibrio spp. in the northwestern Pacific Ocean

Frontiers in Microbiology
In marine ecosystems, Vibrio species are as they facilitate nutrient cycling and impact the condition of marine life. To understand their ecological dynamics and how they adapt to various environmental situations, this study examined the vertical ...
Leihaothabam Jeeny, Leihaothabam Jeeny, Leihaothabam Jeeny, Keyi Huang, Keyi Huang, Keyi Huang, Xing Chen, Xing Chen, Xing Chen, Yan Wang, Yan Wang, Yan Wang, Shaodong Zhu, Shaodong Zhu, Shaodong Zhu, Yulin Zhang, Yulin Zhang, Yulin Zhang, Xiao-Hua Zhang, Xiao-Hua Zhang, Xiao-Hua Zhang, Xiaolei Wang, Xiaolei Wang, Xiaolei Wang   +23 more
doaj   +1 more source

Development of a work instruction system based on analysis of learning processes for cellular manufacturing

Nihon Kikai Gakkai ronbunshu, 2014
Cellular manufacturing systems are well known as flexible manufacturing systems for assembly processes. Single workers carry out all assembly processes of products in the typical cellular manufacturing systems.
Yoshitaka TANIMIZU, Satoru ISHII, Takashi YOKOTANI, Koji IWAMURA, Nobuhiro SUGIMURA   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Higher variability of bacterial communities across space than over time in Antarctic lakes, and contrasting assembly processes

Applied and Environmental Microbiology
As sentinels of environmental changes, Antarctic lakes are ideal systems for studying the temporal and spatial dynamics of microbial communities. However, the relative magnitude and underlying mechanisms driving these variations remain poorly understood.
Diego Ahumada, Guillaume Schwob, Magdalena Osorio, Maria Soledad Astorga, Céline Lavergne, Nazli Olgun, Frederic Thalasso, Elie Poulin, Julieta Orlando, Léa Cabrol   +9 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Insight into diversity change, variability and co-occurrence patterns of phytoplankton assemblage in headwater streams: a study of the Xijiang River basin, South China

Frontiers in Microbiology
Phytoplankton has been used as a paradigm for studies of coexistence of species since the publication of the “paradox of the plankton.” Although there are a wealth of studies about phytoplankton assemblages of lakes, reservoirs and rivers, our knowledge ...
Yuyang Peng, Chuangfeng Wu, Guibin Ma, Haiming Chen, Qinglong L. Wu, Qinglong L. Wu, Dan He, Erik Jeppesen, Erik Jeppesen, Erik Jeppesen, Erik Jeppesen, Lijuan Ren   +11 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Latitudinal Variation in Estuarine Archaeal Biogeography: Deterministic vs. Stochastic Assembly Processes and Network Stability Across China’s Coastal Ecosystems

Microorganisms
Latitudinal gradients are widely recognized as a key macro-environmental driver shaping microbial biogeographic patterns; however, the spatial organization of sediment archaeal communities in estuarine ecosystems and the mechanisms underlying their ...
Yingpai Liu, Guoqing Lv, Zeyu Zhang, Ziyan Fu, Guo Yuan, Jiale Ding, Shuhan Wang, Yingjie Ma, Yaqi Song, Xiaoshuang Zhao, Mao Ye, Yonghui Wang, Zongxiao Zhang   +12 more
doaj   +1 more source