Results 81 to 90 of about 1,602,944 (312)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The concepts and development of a participatory regional integrated assessment tool. [PDF]

, 2008
This paper provides an overview of the development of the ‘Regional Impact Simulator’ – a user friendly software tool designed to allow stakeholders to perform integrated assessments of the effects of climate and/or socio-economic change on the ...
Cojacaru, G., Holman, Ian P., Rounsevell, M.D.A., Rounsevell, M. D. A., Nicholls, R. J., Pearn, K. R., Berry, P. M., Holman, I.P., Nicholls, R.J., Rounsevell, Mark, Pearn, Kerry R., Henriques, C., Harrison, P.A., Mokrech, M., Audsley, E., McLachlan, C., Holman, I. P., Fontaine, C., Richards, J.A., Harrison, P. A., Audsley, Eric, Richards, J. A., Pearn, K.R., Berry, P.M., Shackley, S.   +24 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Using capture and replay for semi-automatic assessment

, 2011
Semi-automatic assessment is a concept that attempts to unify the advantages of computer-aided assessment and tutorial feedback. In the sense of formative assessment, the student should be able to demand feedback not only on her final solution, but also ...
Herding, Daniel, Herding, Daniel Chu, Schroeder, Ulrik   +2 more
core  

Early help in early years: developing a universal assessment tool

, 2018
Effective assessment tools are an essential element of early identification of problems, enabling early intervention in the first two or so years of life.
Spencer, Melinda; id_orcid, Neill, Sarah, Melinda Spencer, Spencer, Melinda, Sarah Church, Redwood, Tracey; id_orcid, Redwood, Tracey, Tracey Redwood, Church, Sarah, Sarah Neill   +9 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Achieving sustainable local tourism management: phase 2 - assessment tool

, 2006
Vols 1, 2: These documents work together to inspire critical assessment of the challenges, issues and opportunities that local governments face. The aim of the guide is to investigate the issues that local governments face in tourism management and the ...
Carson, Dean, Richards, Fiona, Beaumont, Narelle, Macbeth, Jim, Northcote, Jeremy, Dredge, Dianne   +5 more
core  

The Multidimensional Poverty Assessment Tool: a new framework for measuring rural poverty

, 2010
The Multidimensional Poverty Assessment Tool (MPAT) measures fundamental dimensions of rural poverty in order to support poverty-alleviation efforts in the less developed world.
Alasdair Cohen, Cohen, Alasdair
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Sinicization and reliability and validity test of Short Version of the Glaucoma Medication Self⁃Efficacy Questionnaire

Huli yanjiu, 2022
ObjectiveTo translate the Short Version of the Glaucoma Medication Self⁃Efficacy Questionnaire（SVGMSEQ） into Chinese and test its reliability and validity.MethodsThe Chinese version of SVGMSEQ was formed through literal translation，back⁃translation ...
GE Wentao, BIAN Wei, ZHANG Xiaoqin, WANG Lu, WANG Lihua   +4 more
doaj