Results 101 to 110 of about 1,602,944 (312)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Towards automatic generation of e-assessment using semantic web technologies
, 2011 Semantic web technologies have been increasingly used as a tool for generating, organizing and personalizing e-learning content, including e-assessment.
Tosic, Milorad, Cubric, Marija
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Property-level environmental assessment tools for outdoor areas [PDF]
, 2008 There is an increasing interest for building environmental assessment tools in the society. These tools simultaneously consider differing aspects in the built environment although when the aspects most often are of various environmental significance. The
Myhr, Ulla
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Research progress on telecare assessment tools and evaluation indicators
Huli yanjiu, 2019 This paper summarizes the characteristics, reliability and validity of foreign telehealth evaluation tools and indicators, and analyzes the advantages and disadvantages of each evaluation tool and its indicators, so as to provide a reference for the ...
LIU Zhen +5 more
doaj
Huli yanjiu, 2020 This paper reviewed the related studies on cognitive dysfunction in patients with hematopoietic stem cell transplantation(HSCT),And it introduced the research progress of assessment tools and influencing factors of cognitive function of stem cell ...
ZHANG Xiaorong, LIU Minjie, FANG Yun
doaj
Development and Assessment of a Tool to Track and Evaluate Experiential Education Activities
, 2018 Tools such as this can be adapted to other health professions training programs by adapting the tool to collect and present feedback on program- or profession-specific objectives.Applied learning refers to an educational approach where students apply ...
Doloresco, Fred
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