Results 101 to 110 of about 1,218,698 (310)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Research progress of assessment tools for maternal delivery experience

Huli yanjiu, 2021
This article introduced the concept and connotation of maternal delivery experience，and also described the source，reliability and validity，application population，acceptability，and characteristics of 15 maternal delivery experience/satisfaction assessment
XIN Yujie, ZHANG Xian, HU Xiaohui, YAN Wanyu, ZHANG Min   +4 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Developing an Item Bank for Progress Tests and Application of Computerized Adaptive Testing by Simulation in Medical Education [PDF]

, 2019
Progress Test (PT) is a form of assessment that simultaneously measures ability levels of all students in a certain educational program and their progress over time by providing them with same questions and repeating the process at regular intervals with
Atilla Halil ELHAN, Kosan, Aysen Melek Aytug, Koc, Nizamettin, Derya ÖZTUNA, Elhan, Atilla Halil, Oztuna, Derya, Ayşen Melek AYTUĞ KOŞAN, Nizamettin KOÇ   +7 more
core   +1 more source

Addressing challenges of evaluating learners in an ESP course at a tertiary level

Revista de Lenguas para Fines Específicos
Evaluating learners’ performance in an English for Specific Purposes (ESP) course at a tertiary level presents several challenges. These challenges include the diverse needs of learners, the difficulty of developing valid and reliable assessments, and ...
Nazlije Latifaj, Donjete Latifaj, Brikena Xhaferi, Adriana Zafirovska   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Awareness of Emotion Expression Rules in Older Preschoolers: Diagnostics of Cognitive and Behavioral Components

Вопросы образования
Psychological research has established a link between the development of emotion regulation in older preschool children and the growth of their understanding of emotions.
Olga S. Pavlova
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Tools for climate change adaptation in water management - inventory and assessment of methods and tools

, 2010
This report summarizes an inventory of methods and tools for assessing climate change impacts, vulnerability and adaptation options, focusing on the water sector.
Swart, R., Ludwig, F.
core