Results 121 to 130 of about 1,218,698 (310)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Factors influencing ergonomists' use of observation-based risk-assessment tools
, 2019 BACKGROUND: Several observation-based risk-assessment tools have been developed in recent decades. Studies reporting their use often focus only on the user, the ergonomist.
Nyman, Teresia, +2 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
e-Assessment: past, present and future
, 2014 The goal of this paper is to provide an overview of the evolution of electronic assessment, or e-assessment, within the context of a developing e-pedagogy by investigating the changes occurring over time in the ways e-pedagogy is described.
Hench, Thomas
core
Research progress on elderly discrimination in medical field
Huli yanjiu, 2016 It introduced the related concepts,related theory of elderly discrimination,research status quo of elderly discrimination in nursing field of medicine,related factors and assessment tools for elderly discrimination;it puts forward the future research ...
邓珍珍, 刘化侠, 宿婷, 田靖
doaj
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Tools for Integrated Sustainability Assessment: a two-track approach [PDF]
, 2005 Sustainable development has become an overarching policy target for the global policy arena. However, the international policy-making process and that of the individual countries remains largely sectoral in nature: a wide spectrum of international ...
Rotmans, Jan, Rotmans, J. (Jan)
core +1 more source
Computer Adaptive Testing Simulations in R
, 2019 Computer adaptive testing is an important research field in educational measurement, and simulation studies play a critically important role in CAT development and evaluation.
Erdem-Kara, Barak, Basak ERDEM KARA
core +1 more source