Results 121 to 130 of about 345,919 (279)
Advanced Science, EarlyView.Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel +12 more
wiley +1 more source
Asset/Liability Management of German Life Insurance Companies: A Value-at-Risk Approach in the Presence of Interest Rate Guarantees [PDF]
This contribution analyses the implications of two major determinants influencing the asset allocation decision of German life insurers, which are the capital market development on the one hand and the interest rate guarantees of the traditional life ...
Albrecht, Peter, Weber II, Carsten
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Advanced Science, EarlyView.In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia +11 more
wiley +1 more source
Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety
Advanced Science, EarlyView.This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi +15 more
wiley +1 more source
Coherent Asset Allocation and Diversification in the Presence of Stress Events [PDF]
We propose a method to integrate frequentist and subjective probabilities in order to obtain a coherent asset allocation in the presence of stress events.
Denev, Alexander, Rebonato, Riccardo
core +1 more source
Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration
Advanced Science, EarlyView.Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman +5 more
wiley +1 more source
How To Diversify Internationally: A Comparison of Conditional and Unconditional Asset Allocation Methods [PDF]
To obtain the maximum benefits from diversification, financial theory suggests that investors should invest internationally because of the larger potential for risk reduction stemming from the lower correlation exisiting between assets of different ...
Dušan ISAKOV, Laurent BARRAS,
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Advanced Science, EarlyView.Discovery that deadenylation, rather than transcription, acts as the rate‐limiting step for developmental timing in a plant pathogen. Evidence that P‐body integrity and mRNA decay are mechanistically coupled to rapid cellular differentiation under environmental stress. Identification of Pan2‐Pan3 as a pathogen‐specific “meta‐virulence factor” absent in
Ziwei Lv +6 more
wiley +1 more source
Liquidity and Ambiguity: Banks or Asset Markets? [PDF]
We study the impact of ambiguity on two alternative institutions of financial intermediation in an economy where consumers face uncertain liquidity needs.
Jürgen Eichberger, Willy Spanjers
core +3 more sources
Optimal asset allocation for pension funds under mortality risk during the accumulation and ecumulation phases [PDF]
In a financial market with one riskless asset and n risky assets following geometric Brownian motions, we solve the problem of a pension fund maximizing the expected CRRA utility of its terminal wealth.
Francesco Menoncin +2 more
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