Results 61 to 70 of about 8,885,351 (374)

Towards an integrated perspective on fleet asset management: engineering and governance considerations [PDF]

, 2008
The traditional engineering perspective on asset management concentrates on the operational performance the assets. This perspective aims at managing assets through their life-cycle, from technical specification, to acquisition, operation including ...
Kivits, Rob, Mardiasmo, Diaswati, Rosqvist, Tony, Tywoniak, Stephane   +3 more
core   +2 more sources

Is There Too Much Benchmarking in Asset Management?

Social Science Research Network, 2020
We propose a tractable model of asset management in which benchmarking arises endogenously, and analyze its welfare consequences. Fund managers' portfolios are not contractible and they incur private costs in running them.
A. Kashyap, Natalia Kovrijnykh, Jian Li, A. Pavlova   +3 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Raising the bar on the foreign portfolio to 25 per cent: Strategic implications for South African investors

South African Journal of Economic and Management Sciences, 2015
Regulation 28 of the Pension Funds Act now permits an increased allocation of 25 per cent to foreign investments. The regulation previously only permitted a 20 per cent allocation.
David John Bradfield, Brian Munro
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

PHENOMENOLOGY OF THE POWER – GENESIS OF FORMS OF MANIFESTATION OF THE GLOBAL SYSTEM CONTRADICTION 'CREDITORS – DEBTORS'

Вестник Российского экономического университета имени Г. В. Плеханова, 2017
In article on the basis of the new concept of design and functioning of social and economic mechanisms developed by authors the system relationships of cause and effect causing variety of forms of life of a global system contradiction ′creditors reveal ...
Vyacheslav I. Karpunin, Tatiana S. Novashina   +1 more
doaj   +1 more source

Explanatory Change Detection in Financial Markets by Graph-Based Entropy and Inter-Domain Linkage

Entropy, 2022
In this study, we analyzed structural changes in financial markets under COVID-19 to support investors’ investment decisions. Because an explanation of these changes is necessary to respond appropriately to said changes and prepare for similar major ...
Yosuke Nishikawa, Takaaki Yoshino, Toshiaki Sugie, Yoshiyuki Nakata, Kakeru Itou, Yukio Ohsawa   +5 more
doaj   +1 more source

Defining road service to facilitate road infrastructure asset management

, 2020
Road infrastructure asset management requires making decisions that affect how infrastructure provides service – for example, the intervention strategies to follow for specific assets, the interven...
B. Adey, M. Burkhalter, C. Martani
semanticscholar   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Universal pattern in fermion mass ratios and implications for flavor models

European Physical Journal C: Particles and Fields
We show that a single analytic expression using only the labels that distinguish Standard Model mass eigenstates—the ordering index $$d\in \{1,2,3\}$$ d ∈ { 1 , 2 , 3 } and electric charge $$q$$ q —fits all fermion mass ratios with high precision and ...
Samir Varma
doaj   +1 more source