Results 81 to 90 of about 116,983 (244)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

ASSETS - The ASSETS API

, 2011
This is a technical document detailing the ASSETS architecture and API for each component. It integrates and extends results of the first year mainly from T2.0.4 "Platform design and implementation guidelines" and T2.0.5 "API Specifications", but it introduces technical aspects of all the software services defined, analysed, implemented and tested in ...
Briguglio L. Gordea S., Lindley A., Tzoannos E., Meghini C., Cardillo F. A., Esuli A., Falchi F., Ceccarelli D., Bolettieri P., Aloia N., Concordia C., Valdes V., Lopez F., Martinez J. M., Bescos J., Castells P., Garcia M. A., Paytuvi O., Lazaridis M., Beloued A., Spyratos N., Sugibuchi T.   +21 more
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Review on the book: Matveichuk A.A. Oil business in the Russian Empire: Historical essays. Moscow: Drevlekhranilishche, 2025, 256 p. + 16 p. ill.

Вестник Самарского университета: История, педагогика, филология
A high appraisal of the monograph devoted to the history of the oil business in the Russian Empire is given. The significant author’s contribution to the comprehensive disclosure of the subject of the origin, establishing and evolution of the oil ...
V. N. Kuryatnikov
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The Influential Relationship Between Interest Rate Swaps and Earnings: An Analytical Study of Sample Data from Banks in Several Gulf Cooperation Council Countries for the Period 2013-2023

تنمیة الرافدین
This research aims to examine the influence of interest rate swaps on banks' earnings within the context of modern capital markets, characterized by dynamism and continuous development, and to explore the role of derivative financial instruments in risk ...
Zubaida Shukri Hussein Al-Mziri, Shivan Ahmed Mohammed Dusky   +1 more
doaj   +1 more source

Perspectives on knowledge management models [PDF]

Annals of Dunarea de Jos University. Fascicle I : Economics and Applied Informatics, 2009
The purpose of this paper is to present the way some widely used knowledgemanagement models are structured. We will describe the most importantcharacteristics of each model, with our comments about its usefulness inthe economical environment.
Alexandru CĂPAŢÎNĂ, Dragoş Sebastian CRISTEA   +1 more
doaj  

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Strategic asset management in the system of enterprise finance

Фінансово-кредитні системи: перспективи розвитку.
Strategic asset management is gaining particular importance for ensuring the financial stability and long-term development of enterprises in the context of increasing complexity of the business environment, limited resources, and rapid technological ...
Zakharchenko Oleh, Lesya Sarana
doaj   +1 more source