Results 101 to 110 of about 2,109,388 (295)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Grammar Jam: Adding a Creative Editing Tactic

open access: yesPrompt, 2018
The author argues reading, hearing, and then composing musical lyrics involving grammatical concerns can help college writing students to edit more effectively for a song's grammar topic.
David Gillespie
doaj   +1 more source

Assignment Problems [PDF]

open access: yesThe Computer Journal, 1964
Clowes, J. S., Page, E. S.
openaire   +1 more source

Partitioning-based algorithm for pipelined scheduling and module assignment [PDF]

open access: yes, 1991
We propose partitioning-based algorithms for pipeline scheduling, module assignment, and interconnect sharing. A novel hypergraph model is used to perform module assignment which facilitates the identification of sharable resources and the calculation of
Gajski, Daniel D.   +2 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Approximating the multi-level bottleneck assignment problem. [PDF]

open access: yes
We consider the multi-level bottleneck assignment problem (MBA). This problem is described in the recent book 'Assignment Problems' by Burkard et al. (2009) on pages 188-189.
Dokka Venkata Satyanarayana, Trivikram   +2 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Fen ve Teknoloji Dersinde Verilen Ödevlerin Öğrenci Görüşlerine Göre Değerlendirilmesi

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2009
Bu çalışma, ilköğretim okullarının II. kademesindeki öğrencilerin Fen ve Teknoloji derslerinde verilen ev ödevlerine ilişkin görüşlerini değerlendirmek amacıyla yapılmıştır. Araştırmada, survey tarama yöntemi kullanılmıştır.
Caner Aladağ, Süleyman Doğu
doaj  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

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