Results 41 to 50 of about 73,607 (291)

Establishment of a nonshockable rhythm cardiac arrest model caused by asphyxia

BMC Cardiovascular Disorders, 2022
Objective Cardiac arrest (CA) is caused by a nonshockable rhythm with a low success rate of return of spontaneous circulation (ROSC) and a poor prognosis. This study intended to establish a nonshockable rhythm CA model caused by asphyxia.
Chenyu Zhang, Haohong Zhan, Dawang Zhou, Tian Li, Qiang Zhang, Cong Liu, Hongyan Wei, Chunlin Hu   +7 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Association of Residential Proximity to the Coast With Incident Myocardial Infarction: A Prospective Cohort Study

Frontiers in Cardiovascular Medicine, 2022
BackgroundLittle is known about how the residential distance to the coast is associated with incident myocardial infarction (MI) and which mechanisms may explain the association.
Zhuang Xiao-dong, Zhuang Xiao-dong, Zhang Shao-zhao, Zhang Shao-zhao, Hu Xun, Hu Xun, Liao Xin-xue, Liao Xin-xue, Liao Li-zhen, Liao Li-zhen   +9 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction

Frontiers in Cardiovascular Medicine
BackgroundThere is growing evidence that genetic factors may play a crucial role in the development of ventricular fibrillation (VF) following acute ST-segment elevation myocardial infarction (STEMI).
Ying-Ying Ji, Ying-Ying Ji, Yang Wu, Yang Wu, Ji Sun, Ji Sun, Xiao-Xiong Lin, Xiao-Xiong Lin, Xu-Miao Chen, Xu-Miao Chen, Cheng-Cheng Ji, Cheng-Cheng Ji, Li-Juan Liu, Li-Juan Liu, Yun-Jiu Cheng, Su-Hua Wu, Su-Hua Wu   +16 more
doaj   +1 more source

Case Report: Area of Focus of Myocardial Infarction With Non-obstructive Coronary Arteries in Eosinophilic Granulomatosis With Polyangiitis

Frontiers in Cardiovascular Medicine, 2021
Background: Eosinophilic granulomatosis with polyangitis manifested as myocardial infarction with non-obstructed coronary arteries (MINOCA) is rarely reported.Case: We report a 43-year-old male patient without any cardiovascular risk factors presenting ...
Xiaoxian Cui, Yang Peng, Jun Liu, Jun Liu, Yugang Dong, Yugang Dong, Zexuan Wu, Zexuan Wu, Yili Chen, Yili Chen   +9 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Circle the Cardiac Remodeling With circRNAs

Frontiers in Cardiovascular Medicine, 2021
Cardiac remodeling occurs after the heart is exposed to stress, which is manifested by pathological processes such as cardiomyocyte hypertrophy and apoptosis, dendritic cells activation and cytokine secretion, proliferation and activation of fibroblasts,
Tiqun Yang, Tiqun Yang, Tianxin Long, Tianxin Long, Tailai Du, Tailai Du, Yili Chen, Yili Chen, Yugang Dong, Yugang Dong, Zhan-Peng Huang, Zhan-Peng Huang, Zhan-Peng Huang   +12 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source