Results 111 to 120 of about 27,192 (282)

What's So Special About Medically Assisted Dying?

open access: yesCanadian Journal of Bioethics
Critics of Canada’s current medical assistance in dying (MAiD) regime commonly employ two types of argument: 1) that the number of annual provisions shows that it is out of control or on a slippery slope, and 2) that it puts persons with disabilities at
Wayne Sumner
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Euthanasia and Assisted Death

open access: yesپژوهش در دین و سلامت, 2016
For downloading the full-text of this article please click here. Euthanasia phenomenon is one of the major and emerging events in medical sciences which today many issues have been raised about it.
Morteza Abdoljabari   +3 more
doaj  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

open access: yesFEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa   +2 more
wiley   +1 more source

Illuminating the Dilemmas of Assisted Dying - The Clarity Afforded by Orthodox Systems Theory

open access: yes, 2013
In English law, s. 2(1) of the Suicide Act 1961 prohibits rendering assistance in dying to a person, even at their behest. Societal debate and petitions to law reveal agitation for legal change that often is championed in the field of medical or ...

core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Assisted death in eating disorders: a systematic review of cases and clinical rationales

open access: yesFrontiers in Psychiatry
BackgroundAssisted dying for reasons solely related to an eating disorder (ED) has occurred in multiple countries, including those which restrict the practice to individuals with a terminal condition.
Chelsea Roff, Catherine Cook-Cottone
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Moving to the other side of Luhmann's Binary Distinction: Perspectives for Legal Change over Assisted Dying

open access: yes, 2014
An intransigent problem for English law inheres in the desire of some to assist another who wishes to die as an act of benevolence. This is prohibited by law, so creating an impasse. Conceptual correspondence between this and the strictures of Luhmannian
Gilson, C.C.
core  

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