Results 91 to 100 of about 919,210 (272)

Dignity at the end of life

Journal of Interdisciplinary Ethical Research
This article is an academic reworking of three earlier opinion pieces that appeared in The Conversation and on News24. The first focuses on the ethical complexities surrounding the right to die in the South African context, examining arguments both ...
Chris Jones
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Constitution of 'The Already Dying': The Emergence of Voluntary Assisted Dying in Victoria

, 2021
Constitution of 'The Already Dying': The Emergence of Voluntary Assisted Dying in ...
Courtney Hempton (13072809), Catherine Mills (12012077)   +1 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Assisted deaths prior to the Voluntary Assisted Dying Act 2017 (Vic) : would patients have met the eligibility criteria to request voluntary assisted dying?

, 2022
Unlawful assisted dying practices have been reported in Australia for decades. Voluntary assisted dying (VAD) is now lawful in Victoria and Western Australia in limited circumstances and will soon be lawful in a further four Australian States.
Del Villar, K, Yates, P, White, B, Willmott, L, Feeney, R, Mitchell, G, Chambaere, Kenneth   +6 more
core   +1 more source

‘It Simply Required Far Too Many Steps and Made You Feel You Were Just a Number’. Family Caregivers' Experiences With Assisted Suicide in Austria: A Qualitative Study

Health Expectations
Introduction This study examines the lived experiences of family caregivers navigating the legal and emotional complexities of Austria's newly enacted Dying Decree Law.
Tamina‐Laetitia Vielgrader, Ricarda Mewes, Julia Fischer, Jana Marica Hluch, Maria Kletecka‐Pulker, Gudrun Kreye, Elisabeth Lucia Zeilinger   +6 more
doaj   +1 more source

Attitudes towards assisted suicide and euthanasia among care-dependent older adults (50+) in Austria: the role of socio-demographics, religiosity, physical illness, psychological distress, and social isolation

BMC Medical Ethics, 2017
Background Care-dependency constitutes an important issue with regard to the approval of end-of-life decisions, yet attitudes towards assisted suicide and euthanasia are understudied among care-dependent older adults.
Erwin Stolz, Hannes Mayerl, Peter Gasser-Steiner, Wolfgang Freidl   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Assisted dying and Lord Falconer’s recommendations; to what extent should medical and public opinion be considered when amending the law relating to assisted dying? [PDF]

, 2019
Assisted dying in the UK is a controversial topic, this is due to a massive peak in public and medical interest in the topic. This is because of two recent Landmark cases Tony Nicklinson and Debbie Purdy.
Rowley, Calvin, McGrory, Iseult, Lowdon, Dein, Taylor, Colm   +3 more
core   +1 more source