Results 81 to 90 of about 27,192 (282)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reframing assisted dying through the civil law: possibilities and challenges for the UK [PDF]

If assisted dying is legalised in the British Isles, the authors propose that a socio-legal, civil law model is the most pragmatic, socially nuanced and ethical mode of regulation.
Hardes Dvorak, J., Regnard, C., Herx, L., Proffitt, A., Coelho, R.   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Palliative Care and Assisted Dying Laws [PDF]

Proposals are being developed in Scotland, the Isle of Man and Jersey to allow assisted dying for people who are terminally ill, if they request it. Some people oppose legalization because of fears about the effects that assisted dying laws might have on
Gill, Michael, Cholbi, Michael, Colburn, Ben, Pettigrove, Glen, Millum, Joseph   +4 more
core  

Counting the cost of denying assisted dying [PDF]

, 2020
In this paper we propose and defend three economic arguments for permitting assisted dying. These arguments are not intended to in provide a rationale for legalising assisted suicide or euthanasia in and of themselves; rather, they are supplementary ...
Morton, Alec, Shaw, David
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Depression and Assisted Dying

, 2017
This chapter examines the relationship between depression and assisted dying, or euthanasia, by drawing on the metaphor of a ‘black dog’ being ‘put to sleep’.
Richard Huxtable
core   +1 more source

Development of Voluntary Assisted Dying Training in Victoria, Australia: A Model for Consideration

, 2020
Background: Voluntary assisted dying was legalized in Victoria, Australia in June 2019, and was the first jurisdiction internationally to legislatively mandate training for doctors conducting eligibility assessments of patients.
Hewitt, Jayne, Yates, Patsy, White, Ben P, Greaves, Laura Ley, White, Ben P., Parker, Malcolm H, Meehan, Rebecca, Parker, Malcolm H., Close, Eliana, Willmott, Lindy   +9 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Promoting access to voluntary assisted dying: an interpretivist exploratory study of health services in Queensland, Australia

Objective Voluntary assisted dying is a contested practice that some end-of-life care providers choose not to offer to patients. In some jurisdictions, this has restricted access.
Hewitt, Jayne, Bonner, Ann, Wilson, Michael, Bloomer, Melissa J, Rennie, Cooper   +4 more
core   +1 more source