Results 101 to 110 of about 52,542 (290)
Rethinking Design Education: The Role of Universal Design in a Sustainable Future
DIIDThis paper explores the critical gap in integrating Universal Design (UD) into U.S. design education, where sustainability is often prioritized while inclusivity remains elective.
Bruno Oro, Subinay Malhotra
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
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Service Specifications for Assistive Products Fitting in Healthcare Institutions
康复学报China has the largest population in need of assistive products and the greatest market potential in the world. The demand for assistive products fitting services among functionally impaired groups such as the elderly, individuals with disabilities, and ...
BAI Dingqun +12 more
doaj
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
‘Future Bathroom’, What to make? Or How to Make? Challenges in meeting sustainable needs. [PDF]
, 2011 This paper is a case study that describes a design research programme, ‘the future bathroom’, undertaken by the authors which illuminates both challenges and solutions for inclusive and sustainable design. A co-design research methodology was adopted and
Burton, Maria +3 more
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Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Codesigning Solutions for Assistive Technology Service Provision in Queensland, Australia
Health ExpectationsIntroduction Assistive technology (AT) is an essential element of universal healthcare, with a lack of access to AT a worldwide problem. Collaboration between key stakeholders is essential to understand the provision challenges and to generate possible ...
Tammy Aplin +7 more
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