Results 61 to 70 of about 10,756 (248)

Metrology-Assisted Production in Agriculture and Forestry

Sensors
According to the Food and Agriculture Organization of the United Nations, climate change will negatively affect food security and increase pressure on freshwater resources [...]
Bogena, H. R., Brogi, C., Hübner, C., Panagopoulos, A.   +3 more
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Operationalising Article 13 of the Convention on the Rights of Persons with Disabilities the role of assistive technology in ensuring access to justice

Frontiers in Rehabilitation Sciences
Access to justice is a determinant of the realisation of all other rights, including the right to health, employment, and education. As persons with disabilities experience increased discrimination and social exclusion and are at higher risk of violence ...
Joanne McVeigh, Joanne McVeigh, Joanne McVeigh   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Service Specifications for Assistive Products Fitting in Healthcare Institutions

康复学报
China has the largest population in need of assistive products and the greatest market potential in the world. The demand for assistive products fitting services among functionally impaired groups such as the elderly, individuals with disabilities, and ...
BAI Dingqun, XIAO Mingzhao, GONG Weijun, WANG Yulong, WU Shuang, XU Jianwen, YU Hongliu, DING Tao, TAO Chunjing, MA Lifang, YANG Lining, RAO Qianyi, ZOU Hongyan   +12 more
doaj  

The Kenyan assistive technology ecosystem: a network analysis

Global Health Action
Background Assistive technology is central to the realization of the rights of persons with disabilities. However, there remains limited access to assistive technology throughout much of the world, with particularly poor access in lower- and middle ...
Emma M. Smith, Stephanie Huff, Rose Bukania, Bernard Chiira, Catherine Holloway, Malcolm MacLachlan   +5 more
doaj   +1 more source

Effectiveness and usability of artificial intelligence-powered assistive technologies in Supporting daily activities of children with cerebral palsy: a systematic review

Annals of Medicine
Background Cerebral Palsy (CP) is the main cause of motor disabilities in childhood, necessitating innovative approaches to rehabilitation and assistive technology (AT).
Jinglong Li, Qisen Zhu, Mohamad Nabil Mohd Noor, Chan Choong Foong   +3 more
doaj   +1 more source

Assistive technology and passengers with special assistance needs in air transport: contributions to cabin design

Production, 2016
There has been significant growth in air transport worldwide, as well as in Brazil. However, studies have emphasized that disabled, obese, and elderly passengers face difficulties when using this means of transport.
Carina Campese, Talita Naiara Rossi da Silva, Larissa Lunardon Gomes da Silva, Julia Pierre Figueiredo, Nilton Luiz Menegon   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source