Results 71 to 80 of about 9,945 (245)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Improving Satisfaction with Assistive Technology Through Better Service Delivery: Evidence from the WHO rATA Survey in Italy

Technologies
Population-level evidence on how different phases of assistive technology service delivery contribute to user satisfaction with assistive products remains limited, despite its importance for strengthening provision systems.
Lorenzo Desideri, Riccardo Magni, Francesco Zanfardino, Evert-Jan Hoogerwerf, Concetta Vaccaro, Regina Gregori Grgič, Marta De Santis, Rosa Immacolata Romeo, Elena Ilaria Capuano, Sandra Morelli, Antonia Pirrera, Daniele Giansanti   +11 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Experiences of Persons With Disabilities Regarding Home Adaptation and Assistive Products in a Rural Community of Northern Thailand: Qualitative Study

Asian/Pacific Island Nursing Journal
BackgroundChiang Mai Province, located in northern Thailand, is a well-known tourist destination. Its rural areas are characterized by mountainous and valley landscapes, where residents primarily engage in agricultural activities and maintain traditional
Anuchart Kaunnil, Hataichanok Apikomonkon, Jiranan Griffiths, Peeraya Munkhetvit   +3 more
doaj   +1 more source

Preferences of Informal Carers on Technology Packages to Support Meal Production by People Living with Dementia, Elicited from Personalised AT and ICT Product Brochures

Informatics, 2017
Assistive technology (AT) can help support the continued independence of people living with dementia, supported by informal carers. Opinions and preferences of informal carers towards a range of assistive and digital information and communication ...
Maria Laura De Filippis, Michael P. Craven, Tom Dening   +2 more
doaj   +1 more source

Association Between the Availability of Mobility Assistive Products and Participation Outcomes in Individuals With Spinal Cord Injury in Switzerland. [PDF]

Top Spinal Cord Inj Rehabil, 2023
Fong A, Gemperli A, de Vries W.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Rethinking Design Education: The Role of Universal Design in a Sustainable Future

DIID
This paper explores the critical gap in integrating Universal Design (UD) into U.S. design education, where sustainability is often prioritized while inclusivity remains elective.
Bruno Oro, Subinay Malhotra
doaj   +1 more source

Retrospective analysis of low vision assistive products - A 6-year review. [PDF]

Saudi J Ophthalmol, 2023
Gurnani B, Kaur K, Sivakumar P, Bhandari S.   +3 more
europepmc   +1 more source