Results 71 to 80 of about 52,542 (290)

Telehealth: acceptability, clinical interventions and quality of life in peritoneal dialysis [PDF]

open access: yes, 2016
Introduction: Telehealth technologies are being widely adopted across the globe for management of long-term conditions. There are limited data on its use, effectiveness and patient experience in end-stage renal disease.
Dey, Vishal   +2 more
core   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Developing medical device technologies from users' perspectives: A theoretical framework for involving users in the development process [PDF]

open access: yes, 2009
Objectives: The aim of this study was to suggest an acceptable and generic theoretical framework for involving various types of users in the medical device technology (MDT) development process (MDTDP).Methods: The authors propose a theoretical framework ...
Anderson   +7 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

User Driven Innovation: Incorporating Disabled Lead Users in Early Phase Product Development [PDF]

open access: yes, 2014
How can disabled non-designers play a leading role in product development? As part of early phase product ideation, designers often rely on methods (Pahl & Beitz, 1996, Chapter 4).
Conradie, Peter
core  

Fine-Grained Product Class Recognition for Assisted Shopping

open access: yes, 2015
Assistive solutions for a better shopping experience can improve the quality of life of people, in particular also of visually impaired shoppers. We present a system that visually recognizes the fine-grained product classes of items on a shopping list ...
Floerkemeier, Christian   +4 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Placing assistive technology and telecare in everyday practices of people with dementia and their caregivers: findings from an embedded ethnography of a national dementia trial

open access: yesBMC Geriatrics, 2021
Background Policy makers and care providers see assistive technology and telecare as potential products to support people with dementia to live independently in their homes and communities.
Matthew Lariviere   +4 more
doaj   +1 more source

User involvement in healthcare technology development and assessment: Structured literature review [PDF]

open access: yes, 2006
Purpose – Medical device users are one of the principal stakeholders of medical device technologies. User involvement in medical device technology development and assessment is central to meet their needs.
Robinson, I, Shah, SGS
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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