Results 61 to 70 of about 581,434 (217)
Brain Sciences, 2016 This review summarizes current research on the genetics of insomnia, as genetic contributions are thought to be important for insomnia etiology. We begin by providing an overview of genetic methods (both quantitative and measured gene), followed by a ...
Mackenzie J. Lind, Philip R. Gehrman
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito +7 more
wiley +1 more source
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
G3: Genes, Genomes, Genetics, 2016 Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p.G420D) in plasminogen (PLG) as a putative genetic risk factor ...
A. Dessa Sadovnick +53 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Discovery of Resistance Genes in Rye by Targeted Long-Read Sequencing and Association Genetics. [PDF]
Cells, 2022 Vendelbo NM +9 more
europepmc +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma
Respiratory Research, 2001 Asthma is the most common chronic childhood disease in the developed nations, and is a complex disease that has high social and economic costs. Studies of the genetic etiology of asthma offer a way of improving our understanding of its pathogenesis, with
Palmer Lyle J, Cookson William OCM
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Genetics of Type 2 Diabetes Mellitus-Asian Perspective (A Review)
Endocrinology Research and Practice, 2017 Type 2 diabetes mellitus (T2DM) is a metabolic disorder that has come up as a major cause of mortality and continues to cause enormous socio-economic loss across the globe. In the purview of this, a thorough understanding of the pathophysiology, etiology,
Asher FAWWAD, Kanza RASHID, Abdul BASIT
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Building pan-genome infrastructures for crop plants and their use in association genetics. [PDF]
DNA Res, 2021 Jayakodi M +3 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source