Results 91 to 100 of about 5,568,459 (279)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Boosting enjoyment and social inclusion to increase physical activity and reduce sedentary behaviour among older adults: protocol for a feasibility study to test the JOIN4JOY approach in five European countries

BMJ Open
Introduction Programmes for older people aimed at increasing physical activity (PA) and reducing sedentary behaviour (SB) traditionally focus on achieving functional and health improvements.
Laura Coll-Planas, Sergi Blancafort Alias, Paolo Caserotti, Maria Giné-Garriga, Mathias Skjødt, Javier Jerez-Roig, Oriol Sansano-Nadal, Guillaume Lefebvre, Eduard Minobes-Molina, Montse Romero-Mas, Andrea Fuente-Vidal, Erika Karkauskienė, Aimar Intxaurrondo, Dhayana Dallmeier, Lucie Bassinah, Dolores Forgione, Ricard Castro, Carles Parés-Martínez, Blanca Roman-Viñas, José Luis Socorro-Cumplido, Ainhoa Nieto-Guisado   +20 more
doaj   +1 more source

Region-Based Association Test for Familial Data under Functional Linear Models.

PLoS ONE, 2015
Region-based association analysis is a more powerful tool for gene mapping than testing of individual genetic variants, particularly for rare genetic variants.
Gulnara R Svishcheva, Nadezhda M Belonogova, Tatiana I Axenovich   +2 more
doaj   +1 more source

Limitations of principal components in quantitative genetic association models for human studies. [PDF]

Elife, 2023
Yao Y, Ochoa A.
europepmc   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Asymmetry Plus Association Models for Ordinal Square Contingency Tables

Journal of Statistical Theory and Applications (JSTA)
In contingency table analysis, statistical models have been used to study the linkage between variables. The independent model is used to analyze whether or not there is an association between variables.
Kengo Fujisawa, Koki Makishima, Kouji Tahata   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Locally epistatic models for genome-wide prediction and association by importance sampling

Genetics Selection Evolution, 2017
Background In statistical genetics, an important task involves building predictive models of the genotype–phenotype relationship to attribute a proportion of the total phenotypic variance to the variation in genotypes.
Deniz Akdemir, Jean-Luc Jannink, Julio Isidro-Sánchez   +2 more
doaj   +1 more source

Comparison of Single-Trait and Multi-Trait Genome-Wide Association Models and Inclusion of Correlated Traits in the Dissection of the Genetic Architecture of a Complex Trait in a Breeding Program. [PDF]

Front Plant Sci, 2021
Merrick LF, Burke AB, Zhang Z, Carter AH.   +3 more
europepmc   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source