Results 211 to 220 of about 2,123,683 (269)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

A multilevel hierarchical framework for quantification of experimental heterogeneity in population snapshot data. [PDF]

PLoS Comput Biol
Warne DJ, Zhu X, Steele TP, Johnston ST, Sisson SA, Faria M, Murphy RJ, Browning AP.   +7 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Association between <i>H. pylori</i> infection status, UBT-derived DOB level, and colorectal polyp detection. [PDF]

Front Oncol
Zhou Y, Yu G, Huang Z, Wan R.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Association Between MTHFR Gene Polymorphisms and Subclinical Hypothyroidism in Early Pregnancy: A Retrospective Case-Control Study. [PDF]

Int J Womens Health
Liu L, Wang C, Chen X, Zhu Y, Jiao J, Li L, Huang C.   +6 more
europepmc   +1 more source

Association between maternal organophosphate esters metabolite levels during pregnancy and internalizing and externalizing behaviors in children at 2-5 years. [PDF]

Environ Epidemiol
Cheng Y, Abrishamcar S, Ma T, Eick SM, Barr DB, Hoffman N, Andra SS, Chovatiya J, Jagani R, Wright RO, Zar HJ, Stein DJ, Huels A.   +12 more
europepmc   +1 more source

Disentangling the unique associations of age, pubertal stage, and pubertal hormones with white matter microstructure in childhood and adolescence. [PDF]

Imaging Neurosci (Camb)
Curtis M, Yendiki A, Cheng T, Omary A, Flournoy JC, Kandala S, Sanders AFP, Harms MP, Somerville LH, Barch DM.   +9 more
europepmc   +1 more source

Association of the C-reactive protein-triglyceride-glucose index (CTI) with lower-extremity peripheral artery disease among U.S. adults. [PDF]

Atheroscler Plus
Ghay S, Kaur B, Piotrowska A, Barroca C, Mihos CG, Escolar E, Gjergjindreaj M, Wessly P, Elajami TK, Lamas GA, Ujueta F.   +10 more
europepmc   +1 more source