Results 221 to 230 of about 5,612,897 (293)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Rheumatoid arthritis and interstitial lung disease: the role of comorbidities-a retrospective analysis of two RA inception cohorts in the UK. [PDF]

Rheumatology (Oxford)
Dacheva R, Busby A, Kiely P, Young A, Walsh DA, McWilliams DF, Galloway J, Nikiphorou E.   +7 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Association between goiter and type 2 diabetes in a Chinese population: a cross-sectional study using CHNS data. [PDF]

Front Endocrinol (Lausanne)
Song J, Han X, Liu K, Zhai F, Yin D, Zhu X, Hu T.   +6 more
europepmc   +1 more source

Association between mushroom consumption and digit span performance among middle-aged and older community-dwelling Japanese: the NILS-LSA project.

Food Funct
Zhang S, Ba DM, Nishita Y, Tange C, Zhu J, Otsuka R, Muscat J.   +6 more
europepmc   +1 more source

"<i>Echoes from the Dyad</i>": Relational Context of Postpartum Depression Risk. [PDF]

J Clin Med
Tuszyńska-Bogucka W, Bosowska K.
europepmc   +1 more source

Association between admission hemoglobin-to-red blood cell distribution width ratio and stroke-associated pneumonia risk in acute ischemic stroke: effect modification by diabetes status. [PDF]

Front Endocrinol (Lausanne)
Du H, Su X, Huang Q, Yu W, Huang Q, Li X.   +5 more
europepmc   +1 more source

Relative circadian disruption in urinary excretion associates with renal function in biopsy-proven primary glomerular diseases: a cross-sectional study using the novel CRDI metric. [PDF]

Ren Fail
Wang J, Li Y, Xu X, Cai G.
europepmc   +1 more source

Integrating contextual determinants and polygenic risk to examine dementia and late-life cognition in the Multi-Ethnic Study of Atherosclerosis. [PDF]

Alzheimers Dement
Xue D, Hirsch JA, Besser L, Hughes TM, Blue EE, Fitzpatrick AL, Fohner AE.   +6 more
europepmc   +1 more source