Results 71 to 80 of about 29,374,400 (314)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Context, cortex, and associations: a connectionist developmental approach to verbal analogies

Frontiers in Psychology, 2013
We present a PDP model of binary choice verbal analogy problems (A:B as C:[D1|D2], where D1 and D2 represent choice alternatives). We train a recurrent neural network in item-relation- item triples and use this network to test performance on analogy ...
Pavlos eKollias, James L McClelland
doaj   +1 more source

Genetic association models are robust to common population kinship estimation biases. [PDF]

Genetics, 2023
Hou Z, Ochoa A.
europepmc   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Boosting enjoyment and social inclusion to increase physical activity and reduce sedentary behaviour among older adults: protocol for a feasibility study to test the JOIN4JOY approach in five European countries

BMJ Open
Introduction Programmes for older people aimed at increasing physical activity (PA) and reducing sedentary behaviour (SB) traditionally focus on achieving functional and health improvements.
Laura Coll-Planas, Sergi Blancafort Alias, Paolo Caserotti, Maria Giné-Garriga, Mathias Skjødt, Javier Jerez-Roig, Oriol Sansano-Nadal, Guillaume Lefebvre, Eduard Minobes-Molina, Montse Romero-Mas, Andrea Fuente-Vidal, Erika Karkauskienė, Aimar Intxaurrondo, Dhayana Dallmeier, Lucie Bassinah, Dolores Forgione, Ricard Castro, Carles Parés-Martínez, Blanca Roman-Viñas, José Luis Socorro-Cumplido, Ainhoa Nieto-Guisado   +20 more
doaj   +1 more source

Region-Based Association Test for Familial Data under Functional Linear Models.

PLoS ONE, 2015
Region-based association analysis is a more powerful tool for gene mapping than testing of individual genetic variants, particularly for rare genetic variants.
Gulnara R Svishcheva, Nadezhda M Belonogova, Tatiana I Axenovich   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Asymmetry Plus Association Models for Ordinal Square Contingency Tables

Journal of Statistical Theory and Applications (JSTA)
In contingency table analysis, statistical models have been used to study the linkage between variables. The independent model is used to analyze whether or not there is an association between variables.
Kengo Fujisawa, Koki Makishima, Kouji Tahata   +2 more
doaj   +1 more source

Comparison of Single-Trait and Multi-Trait Genome-Wide Association Models and Inclusion of Correlated Traits in the Dissection of the Genetic Architecture of a Complex Trait in a Breeding Program. [PDF]

Front Plant Sci, 2021
Merrick LF, Burke AB, Zhang Z, Carter AH.   +3 more
europepmc   +1 more source