Results 201 to 210 of about 9,104,531 (349)

Amygdala transcranial ultrasound stimulation disrupts threat acquisition and extinction learning. [PDF]

Sci Adv
Fonzo GA, LaBar KS.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Steep delay discounting and addictive behavior: a meta‐analysis of continuous associations

Addiction, 2017
M. Amlung, L. Vedelago, John D. Acker, I. Balodis, J. Mackillop   +4 more
semanticscholar   +1 more source

Daratumumab improved severe neutrophilia and paraneoplastic bone marrow fibrosis in granulocyte‐colony stimulating factor‐producing multiple myeloma

eJHaem
Miki Sakamoto, Kohei Shiroshita, Shinya Fujita, Himari Kudo, Ryohei Abe, Sumiko Kohashi, Yuka Shiozawa, Kuniaki Nakanishi, Takaaki Toyama   +8 more
doaj   +1 more source

Identification of disease ameliorated metabolite candidates from Gut Microbes and their interacting targets based on a novel estimating function. [PDF]

Front Microbiol
Cui H, Liao Z, Kuang X, Zhang JY, Song CY, Liu YJ, Cheng Z, Deng ZX, Guo FB.   +8 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Associations of daily air temperature with lung function and biomarkers of inflammation and oxidative stress in chronic obstructive pulmonary disease. [PDF]

Ann Am Thorac Soc
Ni W, Grady ST, Nassikas N, Hart JE, Koutrakis P, Zhang JJ, Garshick E, Rice MB.   +7 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Appetitive traits and their associations with metabolic health outcomes among adults living with prediabetes: Results from a cross-sectional study. [PDF]

PLoS One
Yildirim AN, Ahluwalia R, Baumgart JK, Cohen TR, Macpherson MM, Jung ME, Purcell SA.   +6 more
europepmc   +1 more source