Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Indocyanine green-assisted chyle leak identification and ligation after left carotid-subclavian bypass: a case report. [PDF]
Soto D +7 more
europepmc +1 more source
Bliver vi smartere af smart teknologi?:Smartphones og tablets invaderer vores hverdag – og vores hjerter. Asterisk har mødt en af teknologifilosofiens store tænkere, den amerikanske professor Don Ihde, til et interview om mekanisk kærlighed, og hvad de nye digitale touch-teknologier vil bringe med sig. [PDF]
Robin Engelhardt
openalex
DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li +25 more
wiley +1 more source
Utilizing High-Throughput Screening of dHL-60 Inflammatory Behaviors to Evaluate Honey-Derived Molecules' Potential as Immunomodulatory Biomaterial Additives. [PDF]
Main EN, Huang JC, Bowlin GL.
europepmc +1 more source
A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Correction: Metabolic interactions between bacterial co-isolates from catheter-associated urinary tract infections. [PDF]
Sokol D +5 more
europepmc +1 more source

