Transient Complete Asthenozoospermia
Journal of Human Reproductive SciencesLimited research exists on the mechanisms underlying asthenozoospermia associated with acquired ciliary dyskinesia. Primary ciliary dyskinesia links respiratory pathology with infertility and provides a basis for a potential mechanism.
Artenisa Kulla +2 more
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BMC Medical Genomics, 2022 Background Asthenozoospermia is a troublesome disease experienced by men in their reproductive years, but its exact etiology remains unclear. To address this problem, this study aims to identify the hub genes and crucial pathways in asthenozoospermia ...
Ci Zou +5 more
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Novel loss-of-function SPAG17 homozygous variant segregated in a family with severe asthenozoospermia: upgrading gene-disease validity to strong [PDF]
Frontiers in EndocrinologyBackgroundSevere asthenozoospermia is a significant cause of male infertility, commonly associated with genetic defects affecting sperm motility. However, the specific genetic contributors remain underexplored.ObjectiveThis study aimed to identify a ...
Li Wang +10 more
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Theranostics, 2021 Rationale: Idiopathic asthenozoospermia (iAZS) is one of the major causes of male infertility and has no effective therapeutic treatment. Understanding the potential mechanisms that cause it may be helpful in seeking novel targets and treatment strategies for overcoming the problem of low sperm motility in iAZS individuals.
Jin, Zi-Run +6 more
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DEFB126 polymorphisms and association with idiopathic asthenozoospermia in China
Asian Journal of Andrology, 2022 Idiopathic asthenozoospermia, a common factor in male infertility, is characterized by altered sperm motility function in fresh ejaculate. Although the β-defensin 126 (DEFB126) protein is associated with asthenozoospermia, DEFB126 gene polymorphisms have
Jiao-Yu He +11 more
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Sperm metabolomic signatures of asthenozoospermia and teratozoospermia in Chinese reproductive-age men [PDF]
Scientific ReportsAsthenozoospermia and teratozoospermia are common causes of male infertility. Despite their prevalence, the underlying metabolic mechanisms remain poorly understood.
Youzhu Li +13 more
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Analysis of ultrastructural defects in sperm by transmission electron microscopy in asthenozoospermia patients: a study from multiple centers across China [PDF]
Biomarker ResearchThis study aimed to identify the ultrastructural features of sperm in Chinese asthenozoospermia patients and to evaluate their clinical implications.
Mo-qi Lv +26 more
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Absence of annulus in human asthenozoospermia: Case Report† [PDF]
Human Reproduction, 2009 The annulus is a septin-based ring structure located at the junction of the midpiece (MP) and the principal piece (PP) of spermatozoa flagellum. In the mouse, deletion of Septin 4, a structural component of the sperm annulus, prevents annulus formation and leads to MP-PP disjunction, flagellar bending, asthenozoospermia and male sterility. Testis anion
P, Lhuillier +8 more
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CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia [PDF]
Molecular Therapy: Nucleic Acids, 2021 Patients with asthenozoospermia often present multiple defects in sperm functions apart from a decrease in sperm motility. However, the etiological factors underlying these multifaceted defects remain mostly unexplored, which may lead to unnecessary ...
Hao Chen +16 more
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Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia [PDF]
Frontiers in EndocrinologyAsthenozoospermia is a severe condition characterized by abnormal sperm motility, contributing to 50% of male infertility cases. Idiopathic asthenozoospermia refers to a form of this condition with no identifiable causes through routine clinical ...
Zilong Wang +10 more
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