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Genetic underpinnings of asthenozoospermia

Best Practice & Research Clinical Endocrinology & Metabolism, 2020
Asthenozoospermia (AZS), defined by reduced motility or absent sperm motility, is one of the main causes of male infertility. This condition may be divided into isolated AZS in the absence of other symptoms and syndromic AZS, which is characterized by several concurrent clinical symptoms.
Chaofeng, Tu   +5 more
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Pentoxifylline Treatment of Asthenozoospermia

Andrologia, 2009
Nine asthenozoospermic men were treated by 1.200 mg/day of pentoxifylline for a period of 2 to 5 months. There was a good response from five patients and the wives of two of these patients became pregnant soon after the last spermatogram was done.
E A, Marsiglia, J, Santillan Eid
openaire   +2 more sources

Relationship between ouabain and asthenozoospermia

Journal of Huazhong University of Science and Technology [Medical Sciences], 2014
A growing number of researches have shown that ouabain can regulate mammalian sperm function and male reproduction by modulating the sperm motility, capacitation and acrosome reaction in vitro. This study further examined the relationship between ouabain and asthenozoospermia.
Yi-Hong, Yang   +4 more
openaire   +2 more sources

Treatment of Asthenozoospermia with HCG

Andrologia, 2009
30 patients with isolated asthenozoospermia received a treatment with 5000 I.U. Human-Chorionic-Gonadotropin (HCG) a week intramuscularly for twelve weeks. Pretreatment basal levels of FSH, LH and testosterone were in normal or low normal range. 16 males responded to therapy, the total motility of spermatozoa increased significantly from 34% to 40%. In
H H, Pusch, P, Pürstner, J, Haas
openaire   +2 more sources

ADGB variants cause asthenozoospermia and male infertility

Human Genetics, 2023
Asthenozoospermia is one of the main factors leading to male infertility, but the genetic mechanisms have not been fully elucidated. Variants in the androglobin (ADGB) gene were identified in an infertile male characterized by asthenozoospermia. The variants disrupted the binding of ADGB to calmodulin.
Ronggui Qu   +16 more
openaire   +2 more sources

ASTHENOZOOSPERMIA: ANALYSIS OF A LARGE POPULATION

Archives of Andrology, 2003
Spermatozoa travel a long distance to meet and fertilize the oocyte, so sperm motility is a requisite for normal fertilization. Asthenozoospermia, or low sperm motility, is a common cause of human male infertility. This is a retrospective study (1992-1999) to document the prevalence of this pathology in infertile men and to clarify the probable factors
S M, Curi   +7 more
openaire   +2 more sources

A novel splicing variant in DNAH8 causes asthenozoospermia

Journal of Assisted Reproduction and Genetics, 2021
To identify the genetic factors responsible for asthenozoospermia, which is a major cause of male infertility characterized by immotile and malformed spermatozoa.Whole-exome sequencing was performed in two brothers from a family with asthenozoospermia to identify pathogenic variants.
Zhou Zhou   +12 more
openaire   +2 more sources

Asthenozoospermia/Teratozoospermia and Infertility

Archives of Andrology, 1990
Abnormal spermiograms with asthenozoospermia and teratozoospermia are often classified as subfertile, and the cause of these findings has been obscure. A new method, the 8-h in vitro motility profile test (MPT), showed a significant difference in motility profile between 130 fertile men and men of infertile couples.
openaire   +2 more sources

LABORATORY METHODS FOR THE DIAGNOSIS OF ASTHENOZOOSPERMIA

Archives of Andrology, 2002
Human sperm samples from 46 men were evaluated for standard semen parameters by two trained technicians, according to WHO criteria. A computer-aided semen analyzer (CASA, HTM-IVOS) was employed. The overall mean coefficient of variation for the 2 participants and the 46 samples studied was 17% for the percentage of progressive motile spermatozoa (r = 0.
S, Curi   +7 more
openaire   +2 more sources

Asthenozoospermia and the human sperm mid-piece

Human Reproduction, 1995
This study provides a quantitative comparison between surface and ultrastructural features of motile spermatozoa in asthenozoospermic and fertile men. The study group consisted of 10 individuals with persistent asthenozoospermia and the controls were 10 fertile donors to a sperm bank.
A J, Mundy, T A, Ryder, D K, Edmonds
openaire   +2 more sources

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