Results 51 to 60 of about 3,577 (174)

Varicocelectomy Restores Spermatogenesis in Fontan‐Associated Varicocele: A Two‐Case Series

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Fontan circulation may cause chronic venous hypertension and predispose patients to varicocele and infertility, but the clinical significance of surgical treatment remains unclear. Case Presentation We describe two patients with Fontan circulation who developed Fontan‐associated varicocele (FAVC).
Yusuke Tominaga, Tomoko Kobayashi, Yuko Matsumoto, Takatoshi Moriwake, Nariaki Ozaki, Takuya Sadahira, Satoshi Katayama, Shingo Nishimura, Kensuke Bekku, Motoo Araki   +9 more
wiley   +1 more source

Association between methylenetetrahydrofolate reductase C677T polymorphisms and male oligozoospermia, asthenozoospermia or oligoasthenozoospermia: a case–control study

Scientific Reports
Mutation of methylenetetrahydrofolate reductase (MTHFR) C677T leads to the decrease of folate utilization and the impairment of spermatogenesis. This study attempts to investigate the association between MTHFR C677T polymorphisms and nonobstructive ...
Fu-jia Ren, Guo-ying Fang, Zhi-yong Zhang   +2 more
doaj   +1 more source

Clinical Features and PLCZ1 Gene Variants in Two Cases of Male Infertility: A Case Series and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
Our study expands the variant spectrum of PLCZ1, enriches the clinical characteristics of PLCZ1, and provides a solid base for the genetic counseling, diagnosis, and treatment of this condition. ABSTRACT Background Variations in the PLCZ1 gene can lead to male infertility (MIM #617214), an autosomal recessive disorder characterized by failure or ...
Jinwei Yang, Bo Yan, Zhizhuo Wei, Zijing Niu, Tongguang Wang, Yan Wei, Fangzhu Wang, Wei Jiang, Lin Zhang, Yue Da, Huanjing Wang, Yali Ni, Zhiqiang Wang   +12 more
wiley   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Absence of annulus in human asthenozoospermia: Case Report† [PDF]

Human Reproduction, 2009
The annulus is a septin-based ring structure located at the junction of the midpiece (MP) and the principal piece (PP) of spermatozoa flagellum. In the mouse, deletion of Septin 4, a structural component of the sperm annulus, prevents annulus formation and leads to MP-PP disjunction, flagellar bending, asthenozoospermia and male sterility. Testis anion
P, Lhuillier, B, Rode, D, Escalier, P, Lorès, T, Dirami, T, Bienvenu, G, Gacon, E, Dulioust, A, Touré   +8 more
openaire   +2 more sources

Use of Pentoxifylline to Improve Seminal Parameters in Dogs

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
A single oral dose of pentoxifylline (10 mg/kg) administered 40 min before ejaculation significantly improved sperm concentration and progressive motility in dogs. The effect was most pronounced in oligospermic subjects, supporting pentoxifylline as a rapid, well‐tolerated adjunct therapy for canine subfertility .
Vincenzo Cicirelli, Matteo Burgio, Lorenza Frattina, Francesco Caprio, Domenico Robbe, Federica Ariu, Annalisa Rizzo   +6 more
wiley   +1 more source

Oxidative Stress‐Related Programmed Cell Death in Male Infertility: Focussing on Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Oxidative stress is a common occurrence in testicular cells of infertile men and is considered a significant cause of male reproductive dysfunction. The increase in reactive oxygen species (ROS) leads to impaired spermatogenesis by activating caspases and generating free radicals from mitochondria, resulting in DNA damage and cell death ...
Nafiseh Sanei‐Ataabadi, Fatemeh Aboutalebi, Kianoush Dormiani, Mohammad Hossein Nasr‐Esfahani   +3 more
wiley   +1 more source

Associations Between Reproductive Disorders and Specific Physical, Mental, Personality, and Social Characteristics: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims The present review aims to ascertain whether reproductive disorders are associated with specific physical, mental, personality, and social traits. This information may be used to support or reject the hypothesis on the origin of infecundity, which proposes that women/men with preferred characteristics, including high ...
Juan J. Tarín, Miguel Ángel García‐Pérez, Antonio Cano   +2 more
wiley   +1 more source

Probiotic Supplementation as an Alternative to Antibiotics in Bovine Sperm Cryopreservation: Effects on Motility, Oxidative Stress and Apoptosis

Reproduction in Domestic Animals, Volume 61, Issue 3, March 2026.
ABSTRACT This study aimed to evaluate the effects of probiotic supplementation on bovine sperm cryopreservation by assessing post‐thaw spermatological and biochemical parameters. Twenty‐four ejaculations were collected from four Simmental bulls using the artificial vagina method.
Ali Doğan Ömür, Demet Çelebi, Serkan Ali Akarsu, Betül Apaydin Yildirim, Gamze Uçak, Tutku Can Acisu, Mehmet Akif Aydin, Sümeyye Başer, Özgür Çelebi, Recep Hakkı Koca, Gözde Arkali, Tarique Hussain   +11 more
wiley   +1 more source

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source