Results 61 to 70 of about 85,562 (306)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Special considerations for adolescent athletic and asthmatic patients

Open Access Journal of Sports Medicine, 2013
Jan C Wuestenfeld,1,2 Bernd Wolfarth1,21Department of Preventive and Rehabilitative Sports Medicine, Technical University Munich (TUM), Munich, Germany; 2Institute for Applied Training Science (IAT), Leipzig, GermanyAbstract: Asthma is defined as a ...
Wuestenfeld JC, Wolfarth B
doaj  

Impact of a 12 weeks supervised exercise training program on pulmonary functions of patients with exercise induced asthma

Egyptian Journal of Chest Disease and Tuberculosis, 2013
Background: Exercise induced bronchoconstriction typically develops within 5–15 min after completing exercise. Patients develop typical asthma symptoms or sometimes troublesome cough, which usually resolve spontaneously within 30–45 min. Previous studies
Helmy A. Heba, Kotb A. Ashraf
doaj   +1 more source

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

The Physical activity as an element of non-pharmacological asthma therapy

Quality in Sport
Asthma is a chronic inflammatory airway disease that is marked by variable airflow limitation and hyperresponsiveness of the airways. Although pharmacologic management remains the mainstay of asthma therapy, physical exercise and other non-pharmacologic
Anna Matuszek, Ewa Siedy-Florek, Zofia Stawowy, Maja Strzeszyna, Katarzyna Szlachetka, Julia Chołda, Wiktoria Janik, Kinga Jamontt, Aleksander Manasar, Magdalena Matlakiewicz   +9 more
doaj   +1 more source

The clinical effectiveness and cost-effectiveness of inhaler devices used in the routine management of chronic asthma in older children: a systematic review and economic evaluation [PDF]

, 2002
Background: This review examines the clinical effectiveness and cost-effectiveness of hand-held inhalers to deliver medication for the routine management of chronic asthma in children aged between 5 and 15 years.
Beverley, C., Lim, J.N.W., Peters, J., Smith, S., Stevenson, M.   +4 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Common respiratory diseases. [PDF]

, 2010
The self-medication phenomenon in upper respiratory tract infections, rhinosinusitis, asthma, and chronic obstructive pulmonary disease are significant and will continue to increase.
Kilgore, David, Najm, Wadie
core  

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Exercise-induced asthma: critical analysis of the protective role of montelukast

Journal of Asthma and Allergy, 2009
Terrence W Carver JrThe Children’s Mercy Hospital and Clinics, Kansas City, MO, USAAbstract: Exercise-induced asthma/exercise-induced bronchospasm (EIA/EIB) is a prevalent and clinically important disease affecting young children ...
Terrence W Carver Jr
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