Cromolyn sodium and masitinib combination inhibits fibroblast‐myofibroblast transition and exerts additive cell‐protective and antioxidant effects on a bleomycin‐induced in vitro fibrosis model [PDF]
Pharmacology Research & PerspectivesIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal fibrotic lung disease. While recent studies have suggested the potential efficacy of tyrosine kinase inhibitors in managing IPF, masitinib, a clinically used tyrosine kinase inhibitor, has ...
Azize Yasemin Göksu +2 more
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Effects of Cromolyn Sodium on Isolated Rat's Trachea [PDF]
Allergy & Rhinology, 2011 Cromolyn sodium (cromolyn) effectively inhibits both antigen- and exercise-induced asthma when used as an aerosol. Intranasal cromolyn is also recommended for preventing and treating allergic rhinitis.
Yuan-Yung Lin M.D. +5 more
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Development and Validation of a Liquid Chromatography-Mass Spectrometry Assay for Determination of Cromolyn Sodium in Skin Permeation Studies [PDF]
Journal of Analytical Methods in Chemistry, 2022 Cromolyn sodium (CS) is a mast cell stabilizer administered to treat allergic diseases. A topical system would sustain its delivery and may be designed for treatment of atopic dermatitis.
Miranda Kay Holman +4 more
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Development of Advanced Chemometric-Assisted Spectrophotometric Methods for the Determination of Cromolyn Sodium and Its Alkaline Degradation Products [PDF]
Molecules, 2020 Advanced and sensitive spectrophotometric and chemometric analytical methods were successfully established for the stability-indicating assay of cromolyn sodium (CS) and its alkaline degradation products (Deg1 and Deg2). Spectrophotometric mean centering
Noha M. El Zahar +2 more
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Improved bioavailability of cromolyn sodium using inhaled PA101 delivered via eFlow® nebulizer [PDF]
European Clinical Respiratory Journal, 2020 In 1960s, cromolyn sodium (CS) has been introduced as the first non-steroidal anti-inflammatory drug for the treatment of allergic and mast-cell driven diseases. Its applicability has been limited due to a poor bioavailability.
Khalid Abd-Elaziz +2 more
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Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13 [PDF]
Respiratory ResearchBackground Sepsis is a systemic inflammatory response caused by infection. When this inflammatory response spreads to the lungs, it can lead to acute lung injury (ALI) or more severe acute respiratory distress syndrome (ARDS).
Cheng Tan +7 more
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Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats [PDF]
BMC Gastroenterology, 2008 Background Mast cells were associated with intestinal ischemia-reperfusion injury, the study was to observe the influence of Ketotifen, Cromolyn Sdium(CS), and Compound 48/80(CP) on the survival rates on the third day after intestinal ischemia ...
Ning Shen +5 more
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Journal of Pharmacy and Bioallied Sciences, 2012 Aim: The current study was aimed to investigate the feasibility of transdermal delivery of cromolyn sodium using a novel lipid vesicular carrier, ethosomes.
R Rakesh, K R Anoop
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Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. [PDF]
PLoS ONE, 2013 BACKGROUND: Acute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. Amplified inflammatory response after transplantation contributes to the process of ALI, but the mechanism underlying inflammation ...
Ailan Zhang +8 more
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Mast cell tryptase-PAR2 axis promotes ovarian fibrosis through RNF152-mediated stabilization of Bcl-xL. [PDF]
Journal of Ovarian ResearchBackground Our research aimed to study the effect and mechanism of tryptase on ovarian fibrosis. Methods The POI mouse model was established by cisplatin at a dose of 1.5 mg/kg for ten days, while the control mice were given the same volume of saline ...
Xiang Zhang, Jun Zhang, Chaojun Wang
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