Results 31 to 40 of about 2,532 (196)

In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)

PLoS ONE, 2021
Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis growth.
Ruben Cloete, Mohd Shahbaaz, Melanie Grobbelaar, Samantha L. Sampson, Alan Christoffels   +4 more
doaj   +2 more sources

Distinct mast cell subpopulations within and around lymphatic vessels regulate lymph flow and progression of inflammatory-erosive arthritis in TNF-transgenic mice

Frontiers in Immunology, 2023
ObjectiveInflammatory-erosive arthritis is exacerbated by dysfunction of joint-draining popliteal lymphatic vessels (PLVs). Synovial mast cells are known to be pro-inflammatory in rheumatoid arthritis (RA).
Yue Peng, Yue Peng, H. Mark Kenney, H. Mark Kenney, Karen L. de Mesy Bentley, Karen L. de Mesy Bentley, Lianping Xing, Lianping Xing, Christopher T. Ritchlin, Christopher T. Ritchlin, Edward M. Schwarz, Edward M. Schwarz   +11 more
doaj   +1 more source

The efficacy of adding oral sodium cromoglycate to stable treatment for controlling bullous pemphigoid-related pruritus: A retrospective study

Frontiers in Medicine, 2022
IntroductionBullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease which mainly affects the elderly. It manifests as severe pruritus, urticarial plaques, and tense bullae and is associated with significant mortality ...
Noy Keller Rosenthal, Darby Boucher, Dedee F. Murrell, Dedee F. Murrell   +3 more
doaj   +1 more source

Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis [PDF]

, 2018
Amyloid-beta protein (Aβ) deposition is a pathological hallmark of Alzheimer’s disease (AD). Aβ deposition triggers both pro-neuroinflammatory microglial activation and neurofibrillary tangle formation.
Shen, Xunuo, Wan, Yu, Tanzi, Rudolph, Elmaleh, David, Ward, Joseph, Forte, Angela M., Hudry, Eloise, Griciuc, Ana, Zhang, Can, Quinti, Luisa, Ran, Chongzhao   +10 more
core   +2 more sources

Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits

Scientific Reports, 2017
This research was conducted to verify the structural and functional characteristics of mast cells in the electroacupuncture (EA) effects on bradycardia. First, we examined the mast cell density at PC 6, adjacent acupoint LU 7, and a non-acupoint.
Haining Zhu, Xuezhi Wang, Meng Huang, Yi Jing, Di Zhang, Guanghong Ding   +5 more
doaj   +1 more source

Additive cell protective and oxidative stress reducing effects of combined treatment with cromolyn sodium and masitinib on MPTP-induced toxicity in SH-SY5Y neuroblastoma cells

, 2022
The suppression of oxidative-stress induced neurotoxicity by antioxidants serves as a potential preventive strategy for neurodegenerative diseases.
Demir Dora, Devrim, Koçancı, Fatma Gonca, Uysal, Hilmi, Göksu Erol, Azize Yasemin   +3 more
core   +1 more source

Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1

, 2013
PMCID: PMC3601088This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Samia Yazid, Solito E., Sinniah Ajantha, Flower R. J., Egle Solito, Yazid S., Solito, E, Rod J Flower, Sinniah, A, Sinniah A., Calder V., Yazid Samia, Ajantha Sinniah, Calder Virginia, Flower Rod J., Flower, RJ, Yazid, S, Virginia Calder, Calder, V, Solito Egle, Rod J. Flower   +20 more
core   +1 more source

Smoldering Systemic Mastocytosis Without Detectable KIT Mutation: A Debilitating Course and Therapeutic Challenge

Cancer Nexus, EarlyView.
Graphical abstract illustrating the clinical course and treatment response. ABSTRACT Systemic mastocytosis (SM) is a clonal hematologic neoplasm driven by activating KIT mutations, particularly D816V. Indolent SM typically follows a stable course, progression to higher‐burden subtypes is uncommon.
Homeniuk Anna, Medina Esenbekova, Micheal Bishara, Layo Akinrinwoye, Leila Metellus, Joane Titus   +5 more
wiley   +1 more source

Effect of Intervention in Mast Cell Function Before Reperfusion on Renal Ischemia-Reperfusion Injury in Rats

Kidney & Blood Pressure Research, 2016
Background/Aims: Mast cells are sparsely distributed in the kidneys under normal conditions; however, the number of mast cells increases dramatically during renal ischemia/reperfusion injury (RI/RI). When mast cells are stimulated, numerous mediators are
Fei Tong, Lei Luo, Daojun Liu
doaj   +1 more source

Resveratrol Suppresses Gut-Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model

Mediators of Inflammation, 2018
Background. Inflammatory responses induced by intestinal ischemia-reperfusion (IIR) lead to serious systemic organ dysfunction and pose a challenge for current treatment.
Weicheng Zhao, Xiaolei Huang, Xue Han, Dan Hu, Xiaohuai Hu, Yuantao Li, Pinjie Huang, Weifeng Yao   +7 more
doaj   +1 more source