Results 31 to 40 of about 565,290 (205)

Evaluation of Histopathological Changes of Long-Term Use of Sodium Cromoglycate on Healthy Rat Nasal Respiratory Mucosa with Light Microscopy

Turkish Archives of Otorhinolaryngology, 2013
Objective:To demonstrate the histopathological effects of the long-term use of cromolyn sodium on healthy rat nasal mucosa using the light microscope.Methods:The animals were grouped according to the intranasal administered agents: first group (n=10 ...
Hande Senem Deveci, İldem Deveci, Pembegül Güneş   +2 more
doaj   +1 more source

Additive cell protective and oxidative stress reducing effects of combined treatment with cromolyn sodium and masitinib on MPTP-induced toxicity in SH-SY5Y neuroblastoma cells

, 2022
The suppression of oxidative-stress induced neurotoxicity by antioxidants serves as a potential preventive strategy for neurodegenerative diseases.
Demir Dora, Devrim, Koçancı, Fatma Gonca, Uysal, Hilmi, Göksu Erol, Azize Yasemin   +3 more
core   +1 more source

STATISTICAL OPTIMIZATION AND EVALUATION OF IN SITU GEL FOR THE OCULAR DELIVERY OF CROMOLYN SODIUM

Objective: The study aimed to develop and optimize cromolyn sodium-based ocular in situ gel to improve the ophthalmic contact period and provide sustained drug release for treating allergic conjunctivitis. Methods: Formulations were prepared using sodium
RATHNANAND, MAHALAXMI, KONDEPATI, HARSHA VARDHANI, NAYAK, DEVIKA, TIPPAVAJHALA, VAMSHI KRISHNA   +3 more
core   +3 more sources

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Effect of Intervention in Mast Cell Function Before Reperfusion on Renal Ischemia-Reperfusion Injury in Rats

Kidney & Blood Pressure Research, 2016
Background/Aims: Mast cells are sparsely distributed in the kidneys under normal conditions; however, the number of mast cells increases dramatically during renal ischemia/reperfusion injury (RI/RI). When mast cells are stimulated, numerous mediators are
Fei Tong, Lei Luo, Daojun Liu
doaj   +1 more source

CXCL10 Promotes Spinal Macrophage Recruitment via the JAK/STAT3 Pathway to Induce Pain in Experimental Autoimmune Prostatitis. [PDF]

Cell Prolif
The CXCL10/CXCR3 axis was involved in spinal macrophage infiltration through activating the JAK/STAT3 pathway. The prostate NGF/TrKA axis was involved in the neuroinflammation and pain in chronic prostatitis, and inhibition of NGF could attenuate pain response in chronic prostatitis, which provided novel therapeutic targets for pain treatment in ...
Chen L, Chen Z, Chen J, Du H, Chen X, Chen J, Wang H, Liang C.   +7 more
europepmc   +2 more sources

Inhibition of NHE1 Overcomes Temozolomide‐Resistance in Glioblastoma via ROS‐AKT/ERK Axis‐Mediated Autophagy Suppression

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
NHE1 inhibition via HOE‐642 suppresses autophagy through the ROS‐AKT/ERK axis, reversing temozolomide resistance in glioblastoma by disrupting the autophagy‐apoptosis balance and enhancing TMZ sensitivity in vitro and in vivo. ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with temozolomide (TMZ) resistance being a ...
Dan Li, Yuhui Li, Xuan Zheng, Zhuo Wang, Yang Wang, Jun Zhang, Jianxiong Guo, Lei Wang, Jingwu Li, Yongliang Liu, Yufeng Li   +10 more
wiley   +1 more source

Resveratrol Suppresses Gut-Derived NLRP3 Inflammasome Partly through Stabilizing Mast Cells in a Rat Model

Mediators of Inflammation, 2018
Background. Inflammatory responses induced by intestinal ischemia-reperfusion (IIR) lead to serious systemic organ dysfunction and pose a challenge for current treatment.
Weicheng Zhao, Xiaolei Huang, Xue Han, Dan Hu, Xiaohuai Hu, Yuantao Li, Pinjie Huang, Weifeng Yao   +7 more
doaj   +1 more source

Beyond Histamine: Mast Cell‐Neuron Communication in Chronic Pruritic and Pain Disorders

Experimental Dermatology, Volume 35, Issue 8, August 2026.
ABSTRACT Chronic pruritic and cutaneous pain disorders are increasingly recognized as neuroimmune conditions driven by dynamic interactions between immune and sensory systems. While histamine has historically dominated models of mast cell‐mediated itch, accumulating evidence indicates that non‐histaminergic pathways are central to chronic disease.
Tomer Kagan, Gil Yosipovitch
wiley   +1 more source

Duration of protective effect of terbutaline sulfate and cromolyn sodium alone and in combination on exercise-induced asthma

, 1990
For subjects with EIA participating in physical activities throughout the day, prolonged duration of protection is desirable. The purpose of this study was to determine whether in EIA a combination of the recommended aerosol doses of the β-adrenergic ...
Woolley, M., Anderson, S. D., Quigley, B. M.   +2 more
core   +1 more source