Results 51 to 60 of about 2,532 (196)

Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions

BMC Pharmacology and Toxicology, 2022
Polysorbate 80 for injection (TW80) is a common excipient used for injection whose macromolecular impurities, including those that cause anaphylactoid reactions, are frequently ignored.
Yue Li, Jinlian Duan, Heng Xia, Yongkun Li, Bin Shu, Weigang Duan   +5 more
doaj   +1 more source

TREATMENT OF INDOLENT AND ADVANCED SYSTEMIC MASTOCYTOSIS

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Management of Indolent and Smoldering SM is focused on preventing anaphylactic reactions, identifying and avoiding symptom triggers. Skin and gastrointestinal symptoms are managed with H1- and H2-antihistamines.
Alessandro Buonomo, Eleonora Nucera, Marianna Criscuolo   +2 more
doaj   +1 more source

Zizhu Ointment Inhibits IgE–FcεRI Signaling‐Mediated Mast Cell Degranulation to Promote the Healing of Diabetic Foot Ulcers

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Diabetic ulcers, a serious complication associated with diabetes, present a significant therapeutic challenge due to their recurrent and persistent chronic inflammation. A crucial factor contributing to this sustained inflammation is mast cell degranulation.
Jian Sun, Xiaoqian Zhang, Meijie Yuan, Xiao Yang, Lei Wang, Hongshuo Shi, Guobin Liu, Yang You, Huantian Cui   +8 more
wiley   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Congestion and Sinonasal Illness in Outer Space: A Study on the International Space Station

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 4, August 2025.
ABSTRACT Objectives This study aims to characterize quantitative data pertaining to sinonasal symptoms and their related medication use aboard the International Space Station (ISS). A secondary focus involves correlating these findings with mission parameters such as extravehicular activity (EVA) participation and mission duration.
Faizaan Khan, Koyal Ansingkar, Roshan Dongre, Zain Mehdi, Aatin K. Dhanda, Kayla Powell, Tariq Syed, Samuel E. Razmi, Isuru Somawardana, Jeffrey T. Vrabec, David Hilmers, Omar G. Ahmed, Masayoshi Takashima   +12 more
wiley   +1 more source

In vitro effects of ketotifen and cromolyn sodium on promastigotes and amastigotes of leishmania major [PDF]

, 2019
Background: The first line treatment against cutaneous leishmaniasis is meglumine antimoniate. This drug is expensive and has serious side effects, including development of drug resistance. Objectives: In this research, because of paucity of information,
Sarouey, L.A., Khanaliha, K., Rahimi-Moghaddam, P., Tabatabaie, F., Dayer, M.S., Khorrami, S.   +5 more
core  

Bronchoconstriction stimulated by airway cooling. Better protection with combined inhalation of terbutaline sulphate and cromolyn sodium than with either alone

, 1983
We compared the effect of inhaled terbutaline sulphate (1,000 μg), cromolyn sodium (20 mg), terbutaline plus cromolyn, and placebo on the response to respiratory heat loss (RHL) in 10 asthmatics in whom terbutaline alone did not completely inhibit the ...
Hargreave, F. E., Latimer, K. M., Morris, M. M., Roberts, R., O'Byrne, P. M.   +4 more
core   +1 more source

Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. [PDF]

PLoS ONE, 2013
BACKGROUND: Acute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. Amplified inflammatory response after transplantation contributes to the process of ALI, but the mechanism underlying inflammation ...
Ailan Zhang, Xinjin Chi, Gangjian Luo, Ziqing Hei, Hua Xia, Chenfang Luo, Yanling Wang, Xiaowen Mao, Zhengyuan Xia   +8 more
doaj   +1 more source

Meta‐Analysis: Evaluating Placebo Rates Across Outcomes in Eosinophilic Oesophagitis Randomised Controlled Trials

Alimentary Pharmacology &Therapeutics, Volume 61, Issue 1, Page 32-43, January 2025.
This meta‐analysis evaluates the response to placebo across multiple outcome domains in eosinophilic oesophagitis trials. While > 40% of patients improve clinically on placebo (influenced by patient age and randomisation ratio), most patients do not improve histologically or endoscopically, highlighting the importance of objective disease assessment ...
Angelica Rivas, Newaz Shubidito Ahmed, Yuhong Yuan, Anila Qasim, David B. O'Gorman, Brian G. Feagan, Vipul Jairath, Albert J. Bredenoord, Evan S. Dellon, Christopher Ma   +9 more
wiley   +1 more source

Eosinophilic Esophagitis (EoE): an emerging disease in childhood - Review of diagnostic and management strategies

Frontiers in Pediatrics, 2014
Eosinophilic esophagitis (EoE) is a chronic immune/antigen mediated inflammatory disease of the esophagus. It comprises a separate entity of increasing incidence and prevalence in children and adults. The disease is characterized by histological evidence
Jorge Amil Dias, Alexandra ePapadopoulou
doaj   +1 more source