Results 51 to 60 of about 4,115 (212)

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Involvement of Polyamines From Cardiac Mast Cells in Myocardial Remodeling Induced by Pressure Overload Through Mitochondrial Permeability Transition Pore Opening

Frontiers in Cardiovascular Medicine, 2022
ObjectivePolyamines mainly contain spermine (SPM), spermidine (SPD), and putrescine (PUT). Many research results suggest that polyamines participate in cell proliferation, differentiation, and the regulation of gene expression, and have a close ...
Xiaolan Xiong, Xiaolan Xiong, Xiaolan Xiong, Junming Li, Shizhong Zhang, Shizhong Zhang, Xiaoli Jia, Xiaoli Jia, Chao Xiao, Chao Xiao   +9 more
doaj   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult

Frontiers in Immunology, 2021
Heterotopic ossification (HO) is one of the most intractable disorders following musculoskeletal injury and is characterized by the ectopic presence of bone tissue in the soft tissue leading to severe loss of function in the extremities.
Juehong Li, Juehong Li, Ziyang Sun, Ziyang Sun, Gang Luo, Gang Luo, Shuo Wang, Shuo Wang, Haomin Cui, Haomin Cui, Zhixiao Yao, Zhixiao Yao, Hao Xiong, Hao Xiong, Yunwei He, Yunwei He, Yun Qian, Yun Qian, Cunyi Fan, Cunyi Fan   +19 more
doaj   +1 more source

Zizhu Ointment Inhibits IgE–FcεRI Signaling‐Mediated Mast Cell Degranulation to Promote the Healing of Diabetic Foot Ulcers

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Diabetic ulcers, a serious complication associated with diabetes, present a significant therapeutic challenge due to their recurrent and persistent chronic inflammation. A crucial factor contributing to this sustained inflammation is mast cell degranulation.
Jian Sun, Xiaoqian Zhang, Meijie Yuan, Xiao Yang, Lei Wang, Hongshuo Shi, Guobin Liu, Yang You, Huantian Cui   +8 more
wiley   +1 more source

Macromolecules in polysorbate 80 for injection: an important cause of anaphylactoid reactions

BMC Pharmacology and Toxicology, 2022
Polysorbate 80 for injection (TW80) is a common excipient used for injection whose macromolecular impurities, including those that cause anaphylactoid reactions, are frequently ignored.
Yue Li, Jinlian Duan, Heng Xia, Yongkun Li, Bin Shu, Weigang Duan   +5 more
doaj   +1 more source

TREATMENT OF INDOLENT AND ADVANCED SYSTEMIC MASTOCYTOSIS

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Management of Indolent and Smoldering SM is focused on preventing anaphylactic reactions, identifying and avoiding symptom triggers. Skin and gastrointestinal symptoms are managed with H1- and H2-antihistamines.
Alessandro Buonomo, Eleonora Nucera, Marianna Criscuolo   +2 more
doaj   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Comparison of efficacy and safety of topical Ketotifen (Zaditen) with Cromolyn sodium in the treatment of Vernal keratoconjunctivitis

Journal of Research in Medical Sciences, 2005
Background: This study compared the efficacy of Ketotifen fumarate .025% (Zaditen) with Cromolyn sodium 4% (Opticrom) eye drops in prevention of itching, tearing, and redness in Vernal Keratoconjunctivitis (VKC). Methods: This double blind ...
MR Shoja, MR Besharaty
doaj  

The Dietary Polyphenol Resveratrol in Intestinal Ischemia–Reperfusion Injury: From Multifaceted Protective Mechanisms to Clinical Translation Challenges [PDF]

Food Sci Nutr
Intestinal ischemia–reperfusion (I/R) injury is a life‐threatening condition with mortality approaching 50%, driven by oxidative stress, inflammatory cascades, ferroptosis, and intestinal barrier disruption that ultimately precipitates distant organ dysfunction.
Zhang X, Huang Z, Zeng Y, Zhang Y, Li P, Wang F, Nie L.   +6 more
europepmc   +2 more sources