Results 51 to 60 of about 565,290 (205)

TREATMENT OF INDOLENT AND ADVANCED SYSTEMIC MASTOCYTOSIS

Mediterranean Journal of Hematology and Infectious Diseases, 2022
Management of Indolent and Smoldering SM is focused on preventing anaphylactic reactions, identifying and avoiding symptom triggers. Skin and gastrointestinal symptoms are managed with H1- and H2-antihistamines.
Alessandro Buonomo, Eleonora Nucera, Marianna Criscuolo   +2 more
doaj   +1 more source

Pro-Tumorigenic Effect of Continuous Cromolyn Treatment in Bladder Cancer. [PDF]

Int J Mol Sci
Globally, bladder cancer is the sixth most frequently diagnosed cancer among men. Despite the increasing availability of immunomodulatory treatments for bladder cancer, the survival rates are still low, which calls for potential new drug-repurposing ...
Franković L, Degoricija M, Gabela I, Vilović K, Korac-Prlic J.   +4 more
europepmc   +2 more sources

Breaking Through the Limits: Nanomedicine at the Service of New Drug Combinations to Tackle Pancreatic Cancer

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 3, May/June 2026.
Pancreatic cancer is a highly aggressive tumor that responds poorly to current therapies. New multi‐drug combinations and/or the use of drug delivery nanosystems may lead to the development of more effective and better‐tolerated treatments for this challenging disease.
Valeria Bincoletto, Ilaria Andreana, Barbara Stella, Nazanine Modjtahedi, Silvia Arpicco, Giorgia Urbinati   +5 more
wiley   +1 more source

Chromones as Nonclassical Inhibitors of Carbonic Anhydrase IX and XII Isoforms: Probing Chromone‐Based Derivatives

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
Chromone‐based derivatives were synthesized and evaluated for selective inhibition of tumor‐associated carbonic anhydrases IX and XII. Structure–activity relationships, docking studies, and ADMET profiling revealed promising candidates with selective tumoral isoform inhibition, supporting their potential as anticancer leads. ABSTRACT A small library of
Lisa Sequeira, Simona Distinto, Carlos Fernandes, Erica Sanna, Rita Meleddu, Marco Gaspari, Filippo Cottiglia, Alessia Onali, Andrea Angeli, Fernanda Borges, Eugenio Uriarte, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni   +13 more
wiley   +1 more source

Cromolyn ameliorates acute and chronic injury in a rat lung transplant model [PDF]

, 2014
BackgroundMast cells have been associated with obliterative bronchiolitis (OB) in human pulmonary allografts, although their role in the development of OB remains unknown.MethodsIn this study, we evaluated the role of mast cells in pulmonary allograft ...
Parker, William, Leung, Jason, Chang, Jui-Chih, Hartwig, Matthew G., Duane Davis, R., Abraham, Soman N., Lin, Shu S., Tang, Tao, Holzknecht, Zoie E.   +8 more
core   +1 more source

The Dietary Polyphenol Resveratrol in Intestinal Ischemia–Reperfusion Injury: From Multifaceted Protective Mechanisms to Clinical Translation Challenges

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Intestinal ischemia–reperfusion (I/R) injury is a life‐threatening condition with mortality approaching 50%, driven by oxidative stress, inflammatory cascades, ferroptosis, and intestinal barrier disruption that ultimately precipitates distant organ dysfunction.
Xue‐feng Zhang, Zhi Huang, Yuan Zeng, Yan Zhang, Ping Li, Fei‐xiang Wang, Liang Nie   +6 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation. [PDF]

PLoS ONE, 2013
BACKGROUND: Acute lung injury (ALI) is one of the most severe complications after orthotopic liver transplantation. Amplified inflammatory response after transplantation contributes to the process of ALI, but the mechanism underlying inflammation ...
Ailan Zhang, Xinjin Chi, Gangjian Luo, Ziqing Hei, Hua Xia, Chenfang Luo, Yanling Wang, Xiaowen Mao, Zhengyuan Xia   +8 more
doaj   +1 more source

Zizhu Ointment Inhibits IgE–FcεRI Signaling‐Mediated Mast Cell Degranulation to Promote the Healing of Diabetic Foot Ulcers

Journal of Diabetes Research, Volume 2026, Issue 1, 2026.
Diabetic ulcers, a serious complication associated with diabetes, present a significant therapeutic challenge due to their recurrent and persistent chronic inflammation. A crucial factor contributing to this sustained inflammation is mast cell degranulation.
Jian Sun, Xiaoqian Zhang, Meijie Yuan, Xiao Yang, Lei Wang, Hongshuo Shi, Guobin Liu, Yang You, Huantian Cui   +8 more
wiley   +1 more source