Results 61 to 70 of about 565,290 (205)

In vitro effects of ketotifen and cromolyn sodium on promastigotes and amastigotes of leishmania major [PDF]

, 2019
Background: The first line treatment against cutaneous leishmaniasis is meglumine antimoniate. This drug is expensive and has serious side effects, including development of drug resistance. Objectives: In this research, because of paucity of information,
Sarouey, L.A., Khanaliha, K., Rahimi-Moghaddam, P., Tabatabaie, F., Dayer, M.S., Khorrami, S.   +5 more
core  

Eosinophilic Esophagitis (EoE): an emerging disease in childhood - Review of diagnostic and management strategies

Frontiers in Pediatrics, 2014
Eosinophilic esophagitis (EoE) is a chronic immune/antigen mediated inflammatory disease of the esophagus. It comprises a separate entity of increasing incidence and prevalence in children and adults. The disease is characterized by histological evidence
Jorge Amil Dias, Alexandra ePapadopoulou
doaj   +1 more source

Bronchoconstriction stimulated by airway cooling. Better protection with combined inhalation of terbutaline sulphate and cromolyn sodium than with either alone

, 1983
We compared the effect of inhaled terbutaline sulphate (1,000 μg), cromolyn sodium (20 mg), terbutaline plus cromolyn, and placebo on the response to respiratory heat loss (RHL) in 10 asthmatics in whom terbutaline alone did not completely inhibit the ...
Hargreave, F. E., Latimer, K. M., Morris, M. M., Roberts, R., O'Byrne, P. M.   +4 more
core   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain

JOR SPINE, Volume 8, Issue 3, September 2025.
This study aims to validate an underutilized canine preclinical model of discogenic back pain model by deep phenotyping several structural and pain associated outcomes with novel findings in the areas of RNA sequencing and whole patch clamp of canine dorsal root ganglion neurons.
Mary K. Heimann, Shirley N. Tang, Gilian Gunsch, Kyle Kuchynsky, Brett Klamer, Fangli Zhao, Megan Co, Maciej Pietrzak, Justin Richards, Jake Klausner, Adam Smith, Kaitlyn Cimney, Sara McBride‐Gagyi, Brad Youngblood, Kara Corps, Candice Askwith, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur   +18 more
wiley   +1 more source

Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats

BMC Gastroenterology, 2008
Background Mast cells were associated with intestinal ischemia-reperfusion injury, the study was to observe the influence of Ketotifen, Cromolyn Sdium(CS), and Compound 48/80(CP) on the survival rates on the third day after intestinal ischemia ...
Ning Shen, Jing Wei, Pin-jie Huang, Xiao-liang Gan, Zi-qing Hei, Wan-ling Gao   +5 more
doaj   +1 more source

Congestion and Sinonasal Illness in Outer Space: A Study on the International Space Station

Laryngoscope Investigative Otolaryngology, Volume 10, Issue 4, August 2025.
ABSTRACT Objectives This study aims to characterize quantitative data pertaining to sinonasal symptoms and their related medication use aboard the International Space Station (ISS). A secondary focus involves correlating these findings with mission parameters such as extravehicular activity (EVA) participation and mission duration.
Faizaan Khan, Koyal Ansingkar, Roshan Dongre, Zain Mehdi, Aatin K. Dhanda, Kayla Powell, Tariq Syed, Samuel E. Razmi, Isuru Somawardana, Jeffrey T. Vrabec, David Hilmers, Omar G. Ahmed, Masayoshi Takashima   +12 more
wiley   +1 more source

G-Protein-Coupled Receptor 35 Is a Target of the Asthma Drugs Cromolyn Disodium and Nedocromil Sodium

, 2010
We report that the asthma drugs cromolyn disodium and nedocromil sodium are potent G-protein-coupled receptor 35 (GPR35) agonists. We utilized calcium flux and inositol phosphate accumulation assays to examine the pharmacology of these asthma drugs on ...
John Whoriskey, Christiaan Saris, Jenny Ying-Lin Lu, Shamin Summer, Yuhua Yang, Xiaosu Wu, Jeff D. Reagan   +6 more
core   +1 more source

A pathway to next-generation mast cell stabilizers identified through the novel Phytomedical Analytics for Research Optimization at scale data platform

Frontiers in Pharmacology
IntroductionMast cell stabilizers (MCS) have the potential to address unmet therapeutic need in allergy and inflammation management. MCS chronically suppress all arms of the pro-inflammatory mast cell response to stimulation (e.g., histamine, protease ...
C. Jansen, B. G. Rice, B. G. Rice, B. Wooton, B. Wooton, J. Howard, J. Howard, S. Elmasri, T. Rivera, L. M. N. Shimoda, A. J. Stokes, C. N. Adra, A. L. Small-Howard, H. Turner, H. Turner   +14 more
doaj   +1 more source

Maintaining Remission in Distal Ulcerative Colitis and Ulcerative Proctitis

Canadian Journal of Gastroenterology, 1990
Maintenance of remission is an important consideration in the medical care of patients with ulcerative colitis. The relapse rate is high when medications are discontinued.
PB Miner, WL Biddle
doaj   +1 more source

(The) bronchodilator effect of cromolyn sodium on methacholine induced bronchoconstriction

, 1985
의학과/석사[한글] Cromolyn sodium은 비만세포막을 안정시켜 화학적 조정기(chemical mediator)의 유리를 억제하여 천식의 예방에 사용되고 있다. 최근 이의 비면역학적인 기관지 수축에 대한 억제효과가 밝혀짐에 따라 비만세포에 작용하는 기전 이외에 다른 여려 작용이 있으리라 추측되어 이에 대한 많은 연구가 진행되고 있다.
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