Results 21 to 30 of about 565,290 (205)

Risks and benefits of asthma therapies

Allergology International, 2000
Maintenance use of short-acting adrenergic agents can cause tachyphylaxis, increased non-specific bronchial hyperreactivity, poorer clinical control, a worsened late allergic reaction and possibly an increased risk of death; therefore, 'as needed' use is
Peter König
doaj   +1 more source

Mast Cell Deficiency Protects Mice from Surgery-Induced Neuroinflammation

Mediators of Inflammation, 2020
Neuroinflammation plays a key role in the occurrence and development of neurodegenerative diseases. Microglia, the resident immune cells in the brain, have been recognized to contribute to neuroinflammation.
Xiang Zhang, Hongquan Dong, Fei Wang, Jun Zhang   +3 more
doaj   +1 more source

The efficacy of adding oral sodium cromoglycate to stable treatment for controlling bullous pemphigoid-related pruritus: A retrospective study

Frontiers in Medicine, 2022
IntroductionBullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease which mainly affects the elderly. It manifests as severe pruritus, urticarial plaques, and tense bullae and is associated with significant mortality ...
Noy Keller Rosenthal, Darby Boucher, Dedee F. Murrell, Dedee F. Murrell   +3 more
doaj   +1 more source

In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)

PLoS ONE, 2021
Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis growth.
Ruben Cloete, Mohd Shahbaaz, Melanie Grobbelaar, Samantha L. Sampson, Alan Christoffels   +4 more
doaj   +2 more sources

Hypokalemic Periodic Paralysis in a Young Woman With Mast Cell Activation Syndrome: A Case Report of an Atypical Presentation Associated With an Ultra-Rare CACNA1S Variant. [PDF]

Clin Case Rep
ABSTRACT Hypokalemic periodic paralysis (hKPP) is a rare neuromuscular channelopathy characterized by transient episodes of muscle weakness or paralysis associated with low serum potassium levels. It has been most commonly linked to autosomal dominant mutations in ion channel genes, specifically CACNA1S and SCN4A, which impair skeletal muscle ...
Moradi A, Aboutaleb Y, Noreen S, Sahyouni A, Sharma H, Oyesanmi O, Kahane IM, Lin Y, Toka HR.   +8 more
europepmc   +2 more sources

Distinct mast cell subpopulations within and around lymphatic vessels regulate lymph flow and progression of inflammatory-erosive arthritis in TNF-transgenic mice

Frontiers in Immunology, 2023
ObjectiveInflammatory-erosive arthritis is exacerbated by dysfunction of joint-draining popliteal lymphatic vessels (PLVs). Synovial mast cells are known to be pro-inflammatory in rheumatoid arthritis (RA).
Yue Peng, Yue Peng, H. Mark Kenney, H. Mark Kenney, Karen L. de Mesy Bentley, Karen L. de Mesy Bentley, Lianping Xing, Lianping Xing, Christopher T. Ritchlin, Christopher T. Ritchlin, Edward M. Schwarz, Edward M. Schwarz   +11 more
doaj   +1 more source

A comparative study of azelastine, cromolyn and olopatadine ophthalmic solution in vernal keratoconjunctivitis in a tertiary care hospital-open label parallel group study design [PDF]

, 2021
Background: Vernal keratoconjunctivitis (VKC) is a chronic, bilateral, external ocular inflammatory disease primarily affecting young boys living in warm, dry climates with seasonal variations.
Sharma, Gaurav, Sawaraj, Sushma, Chaudhary, Kulbhushan P.   +2 more
core   +1 more source

Mast cell activation in the acupoint is important for the electroacupuncture effect against pituitrin-induced bradycardia in rabbits

Scientific Reports, 2017
This research was conducted to verify the structural and functional characteristics of mast cells in the electroacupuncture (EA) effects on bradycardia. First, we examined the mast cell density at PC 6, adjacent acupoint LU 7, and a non-acupoint.
Haining Zhu, Xuezhi Wang, Meng Huang, Yi Jing, Di Zhang, Guanghong Ding   +5 more
doaj   +1 more source

Effect of Chemical and Physical Enhancers on the Skin Permeation of Cromolyn Sodium [PDF]

, 2022
Cromolyn sodium (CS) has clinically shown to be an effective topical remedy for atopic dermatitis, however its physiochemical properties prevent efficient passive drug delivery beyond the outermost skin layer.
Holman, Miranda
core   +1 more source

Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis [PDF]

, 2018
Amyloid-beta protein (Aβ) deposition is a pathological hallmark of Alzheimer’s disease (AD). Aβ deposition triggers both pro-neuroinflammatory microglial activation and neurofibrillary tangle formation.
Shen, Xunuo, Wan, Yu, Tanzi, Rudolph, Elmaleh, David, Ward, Joseph, Forte, Angela M., Hudry, Eloise, Griciuc, Ana, Zhang, Can, Quinti, Luisa, Ran, Chongzhao   +10 more
core   +2 more sources