Results 41 to 50 of about 626,083 (211)

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Mortality from asthma and COPD in Australia [PDF]

, 2014
This report provides information about mortality due to asthma and chronic obstructive pulmonary disease (COPD) in Australia, examining trends over time, seasonal variation, international comparison and variation by age, sex, remoteness, Indigenous ...

core  

A Comprehensive Microbial Gene Catalog of the Human Airway Microbiome Across Anatomical Sites and Geographic Regions

Advanced Science, EarlyView.
An integrated Human Airway Microbiome Gene Catalog (iHAMGC) is constructed from 12,273 metagenomic airway samples, providing a high‐resolution reference of respiratory microbial genes. The catalog enables systematic exploration of taxonomic and functional variation across airway niches and geographic regions, revealing site‐specific and region ...
Qing Zhang, Dashu Li, Bo Liu, Yue Zhang, Min Li, Ruochun Guo, Yawen Ni, Shibin Chen, Biao Ni, Lijie Qiu, Guorui Xing, He Dong, Qiulong Yan, Shenghui Li, Xiaohui Zou, Bin Cao   +15 more
wiley   +1 more source

COPD uncovered: an international survey on the impact of chronic obstructive pulmonary disease [COPD] on a working age population [PDF]

, 2011
Background Approximately 210 million people are estimated to have chronic obstructive pulmonary disease [COPD] worldwide. The burden of disease is known to be high, though less is known about those of a younger age.
Neil Barnes, Jones, P, Walker, S, Fletcher Monica J, Barnes, N, Buist, Sonia A., Buist, SA, Van der Molen, Thys, Barnes Neil, Paul Jones, Walsh, JW, Jenkins Christine, Van Der Molen Thys, Jane Upton, Jenkins, Christine, Walsh John W, Jenkins, C, Upton, J, Van Der Molen, T, Sonia A Buist, Fletcher, Monica J., Hutton John, Fletcher, MJ, Upton, Jane, Walker, Samantha, Taylor-Fishwick Judith, Barnes, Neil, Taylor-Fishwick, J, Jenkins, C ; https://orcid.org/, Walker Samantha, Monica J Fletcher, John Hutton, Thys Van Der Molen, Taylor-Fishwick, Judith, Samantha Walker, John W Walsh, Jones, Paul, Jones Paul, Walsh, John W., Hutton, J, Hutton, John, Buist Sonia A, Upton Jane, Judith Taylor-Fishwick, Christine Jenkins   +44 more
core   +3 more sources

Work absence in patients with asthma and/or COPD: a population-based study

npj Primary Care Respiratory Medicine, 2021
Chronic obstructive pulmonary disease (COPD) and asthma impact on work productivity, but their population-based burden and clinical predictors are understudied.
Boudewijn J. H. Dierick, Bertine M. J. Flokstra-de Blok, Thys van der Molen, Núria Toledo-Pons, Miguel Román-Rodríguez, Borja G. Cosío, Joan B. Soriano, Janwillem W. H. Kocks, Job F. M. van Boven   +8 more
doaj   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Blurred lines. Eosinophilic COPD: ACOS or COPD phenotype?

Revista Portuguesa de Pneumologia (English Edition), 2016
Because asthma and COPD are both inflammatory chronic obstructive airway diseases, there are several clinical expressions which can cause confusion, such as: eosinophilic asthma with fixed obstruction, which is a risk factor and might progress to COPD ...
C.C. Loureiro
doaj   +1 more source

Cognitive Dysfunction in Chronic Rhinosinusitis: A Scoping Review

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Cognitive dysfunction is increasingly recognized as an extra‐nasal manifestation of chronic rhinosinusitis (CRS). This scoping review characterizes the primary evidence on cognition in adult CRS, covering measures, treatment response, and incident dementia.
Luke M. O'Neil, Hannan A Qureshi, Logan Lindemann, David J. Cvancara, Ashton E. Lehmann, Aria Jafari   +5 more
wiley   +1 more source

MANAGEMENT OF ASTHMA-COPD OVERLAP SYNDROME: CLINICAL PHARMACIST PERSPECTIVE [PDF]

Journal of Environmental Science, 2018
Patients with asthma-COPD overlap have more severe symptoms than those with either asthma or COPD alone, experiencing more frequent and more severe exacerbations and more frequent hospitalizations.
Farrag, Rana, R., Zaki, M. A., El-Naggar, T.   +2 more
doaj   +1 more source

Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients

The Anatomical Record, EarlyView.
Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey, Benoît Beyer, Elena García‐Vargas, Isabel Torres‐Sánchez, Francisco García‐Río, Markus Bastir   +5 more
wiley   +1 more source