Results 111 to 120 of about 157,671 (305)

Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC

Communications Biology
Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROTAC) degrader ...
Thomas G. Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L. Braybrooke, Andrew Campbell, Rodrigo J. Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R. Diène, Charlene Fallan, David I. Fisher, Frederick W. Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G. Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J. Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J. Morrow, Myria Nikolaou, J. Willem M. Nissink, Patrick O’Shea, Radoslaw Polanski, Markus Schade, James S. Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter   +35 more
doaj   +1 more source

KONSTRUKSI PEMBERITAAN EFEK SAMPING VAKSIN ASTRAZENECA PADA MEDIA ONLINE KOMPAS.COM DAN DETIK.COM

, 2023
The spread of the corona virus is so fast almost to all corners of the world, including to Indonesia. Various kinds of policies carried out by the Indonesian government to ward off this virus, one of which is the vaccination policy.
Sholihul Abidin, Marbun, Angel Mei
core  

SARS-CoV-2 antibody status of AstraZeneca vaccinated persons.

SARS-CoV-2 antibody status of AstraZeneca vaccinated persons.
Issabella Asamoah (17941272), Allen Steele-Dadzie (17941281), Kwamena W. C. Sagoe (17334446), Albert Turkson (17941287), Quaneeta Mohktar (17563371), Bright Adu (133241), Atta Senior Kuffour (17941284), Kantanka Addo-Osafo (3498869), Priscilla Vandyck-Sey (17941278), Yaw A. Afrane (8491401), Mildred Adusei-Poku (17941275), Ivy Asantewaa Asante (13783364)   +11 more
core   +1 more source

Preguntes sobre la represa de la vacuna amb Oxford/AstraZeneca [fullet]

, 2021
Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Reanudación; Vacuna; Oxford / AstraZenecaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Resumption; Vaccine; Oxford / AstraZenecaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Represa; Vacuna; Oxford ...

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Geminal Difunctionalization of Ketones via C─S Bond Insertion of Photogenerated Donor–Donor Diazo Compounds

Angewandte Chemie International Edition, EarlyView.
Geminal difunctionalization of readily available building blocks provides rapid access to molecular complexity. This work introduces a strategy for installing two distinct functional groups on a carbonyl carbon by transforming it into a donor–donor diazo compound, enabling both batch and flow applications with broad solvent compatibility.
Vincent George, Aryaman Pattanaik, Daniel Maddox, Lukas M. Sigmund, Giovanna Mejia, Sara Pahlén, Simon O. Angerer, Maria Schmoll, Lisa Marie Schneider, Nidhal Selmi, Mikhail Kabeshov, Giulia Bergonzini, Julia Rehbein, Burkhard König   +13 more
wiley   +1 more source

Enhanced patient selection with quantitative continuous scoring of PD-L1 expression for IO treatment in metastatic NSCLC

npj Precision Oncology
Immune checkpoint inhibitors targeting PD-1/PD-L1 are approved for metastatic non-small-cell lung cancer treatment. In clinical practice, the treatment choice depends on visual scoring of PD-L1, which is subjective and semi-quantitative. In this work, we
J. Lesniak, M. Schick, T. Kunzke, F. Pollastri, J. P. Vigueras-Guillén, H. Hessel, S. Haneder, P. Sontakke, K. DaCosta, R. Alleze, J. Zimmermann, A. Kapil, N. Brieu, A. Shumilov, H. Sade, J. C. Barrett, G. Schmidt, R. Stewart   +17 more
doaj   +1 more source

Evaluating the Potential Infectious Risk Profile of Biologics in Chronic Rhinosinusitis With Nasal Polyposis

International Forum of Allergy &Rhinology, EarlyView.
Maxime Fieux, Philippe Gevaert, Leigh J. Sowerby   +2 more
wiley   +1 more source

The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer

npj Breast Cancer
Loss of PTEN expression, via homozygous or hemizygous deletion, is common in PIK3CA mutant ER + BC tumors. We assessed reduction of PTEN protein expression on AKT inhibitor capivasertib efficacy in PIK3CA altered tumors.
Valentina Cutano, Ming Li Chia, Eleanor M. Wigmore, Lorna Hopcroft, Stuart C. Williamson, Amanda L. Christie, Brandon Willis, James Kerr, Jenny Ashforth, Rhys Fox, Sophie D’Arcy, Lauren Bradshaw, Catherine Blaker, Cath Eberlein, Lambert Montava-Garriga, Elza C. de Bruin, Susan E. Critchlow, Kevin M. Brindle, Simon T. Barry, Susana Ros   +19 more
doaj   +1 more source

Anifrolumab Treatment Leads to Rapid Reduction in Urinary Biomarkers of Intrarenal Inflammation in Lupus Nephritis: Results From the Phase 2 Randomized Trial

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon signaling. Anifrolumab, an approved treatment for patients with SLE, has been investigated in a phase 2 trial in patients with LN receiving standard therapy (TULIP‐LN, ClinicalTrials.gov identifier ...
Andrea Fava, Michelle Petri, Patrick G. Gavin, Eszter Csomor, Philip Z. Brohawn, Daniel Muthas, Adam Platt, Catharina Lindholm, Nicola Ferrari   +8 more
wiley   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source