Results 91 to 100 of about 157,671 (305)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

The Hill-AstraZeneca Breakfast Policy Briefing

, 2009
The Hill-AstraZeneca Breakfast Policy ...
Baucus, Max S.
core  

Effect of Budesonide Nasal Irrigation in Patients With Chronic Rhinosinusitis With Nasal Polyps Without Prior Sinus Surgery: A Randomized, Double‐Blind, Placebo‐Controlled Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The indication for nasal irrigation with corticosteroids after sinus surgery in patients with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is well established, as surgery facilitates distribution throughout the sinonasal cavity.
Juliana Sant'Ana, Isabela Pontes, Caio Floriano, Renato Rios, Marlos Cortez, Marcel Miyake   +5 more
wiley   +1 more source

Uncovering the regional localization of inhaled salmeterol retention in the lung

Drug Delivery, 2018
Treatment of respiratory disease with a drug delivered via inhalation is generally held as being beneficial as it provides direct access to the lung target site with a minimum systemic exposure.
Erica Bäckström, Gregory Hamm, Anna Nilsson, Britt-Marie Fihn, Nicole Strittmatter, Per Andrén, Richard J. A. Goodwin, Markus Fridén   +7 more
doaj   +1 more source

Dosing Interval Extension of Dupilumab in CRSwNP: Five‐Year Real World Outcomes

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a persistent, often Type 2‐mediated inflammatory disease that markedly impairs quality of life. While dupilumab provides rapid improvement, there is limited evidence on long‐term outcomes beyond 2 years, and the clinical impact of dosing‐interval extension remains unclear.
Nicholas J. Campion, Dioni‐Pinelopi Petsiou, Florian C. Fally, Karina Berbalk, Noah F. Melamed, Aldine Tu, Christina Morgenstern, Fana Alem Kidane, Mohammed Zghaebi, Linda Liu, Minghao Pan, Tina J. Bartosik, Victoria Stanek, Katarina Gangl, Julia Eckl‐Dorna, Sven Schneider   +15 more
wiley   +1 more source

Extent of Sinus Surgery Is Associated With Disease Control in Biologic Treated Type 2 Dominant CRS

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background A greater benefit of biologics is observed after surgery in Type 2 chronic rhinosinusitis with nasal polyps (CRSwNP). However, the extent of surgery remains undefined in many studies. This study evaluated the extent of surgery on disease control in patients receiving biologics for refractory Type 2 dominant CRSwNP.
Nicholas J. Campion, Peta‐Lee Sacks, Lu Hui Png, Ruoxin Hua, Rhea Darbari Kaul, Raquel Alvarado, Christine Choy, Raymond Sacks, Peter Earls, Raewyn G. Campbell, Larry Kalish, Richard J. Harvey   +11 more
wiley   +1 more source

Over 18 and considering AstraZeneca? This may help you decide

, 2021
If you are 18 or older, and in an area where there is a COVID-19 outbreak, the best vaccine for you is the one you can get right now. That possibly means you should get the AstraZeneca vaccine, as Pfizer is still in short supply.This updated advice was ...
Yates, Natasha
core  

Real-World Clinical Characteristics, Treatment Patterns, and Clinical Outcomes in US Patients with Stage I–III Resected NSCLC Without Known EGFR Mutations: The RESECT Study

Drugs - Real World Outcomes
Background Immunotherapy has altered the treatment landscape for resectable non-small cell lung cancer, increasing the complexity of treatment planning.
Jhanelle E. Gray, Rachel J. Salomonsen, Ignacio Diaz Perez, Alice Wang, Ling Cai, Graham Wetherill, Yang Xiao, Claire Fielden, Nefeli Georgoulia   +8 more
doaj   +1 more source

Brevi note sulla controversia relativa alla fornitura del vaccino AstraZeneca

, 2021
La questione del rispetto del contratto di acquisto di vaccino, l’ormai celebre APA (Advanced Purchase Agreement), stipulato tra la Commissione e la società anglo-svedese AstraZeneca sta avvelenando i rapporti tra l’Unione europea e il Regno Unito, già
Pietro Manzini
core  

Budgetstyrning i ett läkemedelsföretag - En studie på AstraZeneca R&D [PDF]

, 2003
Bakgrund och problem: Verksamheten på AstraZeneca R&D består av projekt i vilka aktiviteter med olika start- och slutpunkter bedrivs. Projektens styrning sker med hjälp av årsbaserade budgetar.
Magnusson, Mats, Gustavsson, Malin
core