Results 71 to 80 of about 226,969 (309)

In silico ADME in drug design – enhancing the impact

ADMET and DMPK, 2018
Each year the pharmaceutical industry makes thousands of compounds, many of which do not meet the desired efficacy or pharmacokinetic properties, describing the absorption, distribution, metabolism and excretion (ADME) behavior.
Susanne Winiwarter, Ernst Ahlberg, Edmund Watson, Ioana Oprisiu, Mickael Mogemark, Tobias Noeske, Nigel Greene   +6 more
doaj   +1 more source

Пресс-релиз компании AstraZeneca

Клиническая онкогематология, 2021
Таргетная монотерапия препаратом Калквенс® (акалабрутиниб) рекомендована Национальным институтом здравоохранения и совершенствования медицинской помощи Великобритании (NICE) для пациентов с хроническим лимфоцитарным лейкозом.
doaj   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto, Umberto Pensato, Ilaria Casetta, Giorgio U. Marcello, Angelo Barra, Anna Poggesi, Edoardo Carlesi, Sara Mancini, Andrea Ginestroni, Vittorio Miele, Alessandro Padovani, Andrea Morotti, Enrico Fainardi   +12 more
wiley   +1 more source

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Communications Biology, 2021
Claire Patterson et al. present the design and development of AZD0466, a drug-dendrimer conjugate, and use preclinical and mathematical models to determine the optimal release rate of the drug from the dendrimer carrier for maximal therapeutic index in ...
Claire M. Patterson, Srividya B. Balachander, Iain Grant, Petar Pop-Damkov, Brian Kelly, William McCoull, Jeremy Parker, Michael Giannis, Kathryn J. Hill, Francis D. Gibbons, Edward J. Hennessy, Paul Kemmitt, Alexander R. Harmer, Sonya Gales, Stuart Purbrick, Sean Redmond, Matthew Skinner, Lorraine Graham, J. Paul Secrist, Alwin G. Schuller, Shenghua Wen, Ammar Adam, Corinne Reimer, Justin Cidado, Martin Wild, Eric Gangl, Stephen E. Fawell, Jamal Saeh, Barry R. Davies, David J. Owen, Marianne B. Ashford   +30 more
doaj   +1 more source

An Empirical Model for Durations in Stocks [PDF]

This paper considers an extension of the univariate autoregressive conditional duration model to which durations from a second stock are added. The model is empirically used to study durations in two traded stocks, Ericsson B and AstraZeneca, on the ...
Simonsen, Ola
core   +1 more source

Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment [PDF]

, 2016
Background: Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients experience relapses with a median ...
Caruso, Davide, Papa, Anselmo, Strudel, Martina, Tomao, Federica, Tomao, Silverio   +4 more
core   +2 more sources

InternationaL cross-sectIonAl and longItudinal assessment on aSthma cONtrol in European adult patients : the LIAISON study protocol [PDF]

, 2013
The study is funded by Chiesi Farmaceutici S.p.A., Parma, ItalyPeer reviewedPublisher ...
AC McLeish, AH Briggs, AH Liu, David Price, DE Morisky, DE Morisky, E Mehuys, ED Bateman, EF Juniper, EF Juniper, Eleonora Ingrassia, Fulvio Braido, G Bettoncelli, Gabriele Nicolini, Guy Brusselle, Heinrich Worth, HK Reddel, J Bousquet, J Haughney, JB Soriano, Joan B Soriano, KF Rabe, KF Rabe, L Allegra, L Cazzoletti, M Mintz, ML Levy, MR Partridge, Nicolas Roche, P Demoly, P Demoly, PJ Honkoop, PM O’Byrne, PO Ehrs, R De Marco, RA Nathan, RH Stanford, S Accordini, SA Williams, V Van der Meer   +39 more
core   +3 more sources

Heme metabolism genes Downregulated in COPD Cachexia. [PDF]

, 2020
IntroductionCachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes.
Agusti, Alvar, Arora, Itika, Bhatt, Surya P, Casaburi, Richard, Castaldi, Peter J, Dransfield, Mark T, Hersh, Craig P, Kumar, Preeti L, Lee, Sool, Lomas, David A, McDonald, Merry-Lynn N, Morrow, Jarrett D, Parker, Margaret M, Rennard, Stephen I, Silverman, Edwin K, Tal-Singer, Ruth, Thannickal, Victor J, Tiwari, Hemant K, Washko, George, Wells, J Michael, Wilson, Ava C, Wouters, Emiel FM   +21 more
core   +3 more sources

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study [PDF]

, 2016
Background: Serious inhaler technique errors can impair drug delivery to the lungs. This randomised, crossover, open-label study evaluated the proportion of patients making predefined serious errors with Pulmojet compared with Diskus and Turbohaler dry ...
A Palander, A Papi, Anne Burden, AS Melani, BL Laube, Catherine Hutton, D Price, D Price, D Price, D Price, David B. Price, Dawn Shan, E Mehuys, Erika Sims, F Lavorini, F Yildiz, Federico Lavorini, GK Crompton, GN Rootmensen, H Al-Jahdali, H Chrystyn, Henry Chrystyn, IA Basheti, J Haughney, J Haughney, J Palen van der, J Steier, JC McElnay, JC Virchow, JL Rau, John Efthimiou, John Haughney, KG Nielsen, L Borgstrom, M Molimard, M Molimard, M Moller, M Schulte, MA Crane, Mathieu Molimard, MS Blaiss, Nicolas Roche, PN Dekhuijzen, RA Al-Showair, S Verver, Sinthia Bosnic-Anticevich, SP Newman, SZ Bosnic-Anticevich, V Giraud, V Giraud, V Giraud, W Azouz, Y Aydemir   +52 more
core   +2 more sources