Results 51 to 60 of about 157,671 (305)

Programmed Cell Death Ligand 1 Expression in Untreated EGFR Mutated Advanced NSCLC and Response to Osimertinib Versus Comparator in FLAURA

, 2019
INTRODUCTION: EGFR mutated (EGFRm) NSCLC tumors occasionally express programmed cell death ligand 1 (PD-L1), although frequency and clinical relevance are not fully characterized.
John, Thomas, Kohlmann, Alexander, Scott, Marietta, Ramalingam, Suresh S, Todd, Alexander, Nakagawa, Kazuhiko, Brown, Helen, Barker, Craig, Ramalingam, Suresh S., Markovets, Aleksandra, Cobo, Manuel, Saggese, Matilde, Vansteenkiste, Johan, Chmielecki, Juliann   +13 more
core   +1 more source

Konsep al-Ḍarūrah Tentang Vaksin Astrazeneca Perspektif Majelis Ulama Indonesia: The al-Ḍarūrah Concept of Astrazeneca Vaccine in the Perspective of Indonesian Ulama Assembly

, 2022
This study aims to comprehensively describe the general overview of al-ḍarūrah and the AstraZeneca vaccine, examine the analysis of fiqh principles regarding al-ḍarūrah in the use of the AstraZeneca vaccine by the MUI, and analyze the MUI fatwa Number 14
Jamaluddin, Jamaluddin, Kasjim Salenda, Abdul Wahid Haddade   +2 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Die Medizin der Zukunft braucht ein modernes AMNOG

Monitor Versorgungsforschung
Im Koalitionsvertrag steht: „Wir werden Deutschland zum weltweit innovativsten Chemie-, Pharma- und Biotechnologiestandort machen.“ Das ist eine kluge Entscheidung.
Alexandra Bishop
doaj   +1 more source

Evaluation of the effectiveness and adverse effects of COVID-19 vaccines administered at Kashan University of Medical Sciences [PDF]

International Archives of Health Sciences
Objectives: The development of protective immunity through COVID-19 vaccines is influenced by both host factors and the composition of the vaccine. Therefore, it is essential to assess the efficacy and side effects of different vaccines among individuals
Zahra Soleimani, Kamal Esalatmanesh, Mohammad Mehdi Safaaddin Kashani, Mohamadjavad Azadchehr, Roozbeh Esalatmanesh   +4 more
doaj   +1 more source

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source

Assessment of Some Immunological Parameters Postvaccination with Different Types of COVID-19 Vaccines

Medical Journal of Babylon
Background: Coronavirus disease 2019 (COVID-19) is a highly contagious viral infection that can spread rapidly worldwide. Several vaccines have been developed to combat COVID-19.
Haneen Saad Khasbak, Hayder Shkhair Al-Janabi, Mohanad Jawad Kadhim   +2 more
doaj   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Factors influencing COVID-19 vaccine breakthrough infections: an analysis of healthcare workers in Ardabil, Iran [PDF]

Health Science Monitor
Background & Aims: Investigating re-infection with COVID-19 is necessary due to the existence of genetic differences among populations after a general vaccination plan. In addition to genetic differences, gender, age, the presence of underlying diseases,
Elham Rezaei, Shafagh Aliasgarzadeh, Sevda Mikaeili mirak, Faraz Tayyar-Iravanlou   +3 more
doaj  

In silico ADME in drug design – enhancing the impact

ADMET and DMPK, 2018
Each year the pharmaceutical industry makes thousands of compounds, many of which do not meet the desired efficacy or pharmacokinetic properties, describing the absorption, distribution, metabolism and excretion (ADME) behavior.
Susanne Winiwarter, Ernst Ahlberg, Edmund Watson, Ioana Oprisiu, Mickael Mogemark, Tobias Noeske, Nigel Greene   +6 more
doaj   +1 more source