Results 101 to 110 of about 46,157 (226)

IGFBP7+ subpopulation and IGFBP7 risk score in astrocytoma: insights from scRNA-Seq and bulk RNA-Seq

Frontiers in Immunology
BackgroundGlioma is the predominant malignant brain tumor that lacks effective treatment options due to its shielding by the blood-brain barrier (BBB).
Liang Zhao, Wenwen Shao, Zhikai Xiahou, Li Ren, Chaobo Liu, Yanbing Song, Hao Xu, Zhihan Wang, Jin Xing   +8 more
doaj   +1 more source

A 3‐year‐old girl with a left optic nerve tumor

Brain Pathology, EarlyView.
Samuel López Muñoz, Alberto Berjón, Carlos Rodríguez Antolín, Claudia Sánchez Lara, Marta Mendiola, Victoria Heredia Soto, Álvaro Lassaletta, Carlos González Pérez, Pedro Rubio Aparicio, Jorge Zamorano, Isabel Esteban Rodríguez   +10 more
wiley   +1 more source

Transverse Relaxation Time Constant of Cystathionine in Human Glioma at 3 T

Magnetic Resonance in Medicine, Volume 96, Issue 3, Page 1076-1082, September 2026.
ABSTRACT Purpose Cystathionine (Cth) has emerged as a promising biomarker for identifying 1p/19q codeleted gliomas. However, little is known about the T2 relaxation time constant of Cth in gliomas. The aim of this study was to measure the T2 of Cth in vivo in glioma and compare it to the T2s of other metabolites at 3 T.
Dinesh K. Deelchand, Francesca Branzoli, Jamie D. Walls, Lucia Nichelli, Marc Sanson, Bertrand Mathon, Małgorzata Marjańska   +6 more
wiley   +1 more source

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

Molecular Hybridization of Clinically Relevant P2X7 Antagonists

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
We employed a molecular hybridization strategy, combining clinically validated antagonists AZD‐9056 and JNJ‐54175446, to design and synthesize a library of novel adamantane‐containing P2X7R antagonists. Pharmacological and in silico analyses indicate that these adamantyl hybrids adopt a distinct, shallow binding mode within the P2X7R allosteric pocket,
Nicholas B. Lynch, Charleigh T. A. Agius, André D. J. McKenzie, Jessica O’Driscoll, Angus Tolmie, Taylor R. Garrett, Eryn Werry, Michael Kassiou   +7 more
wiley   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Suprasellar pilocytic astrocytoma with leptomeningeal dissemination

South African Journal of Radiology
Leptomeningeal dissemination is a rare manifestation of pilocytic astrocytoma. It may occur with higher-grade tumours like medulloblastoma, ependymoma and high-grade glioma, but is extremely rare with low-grade glioma.
Siti S. Mohamad Zaini, Hilwati Hashim, Emy S. Rosani, Nor S. Bakar, Suryati Mohd Yusuf   +4 more
doaj   +1 more source

Assessing Cognitive Functioning in Children With Brain Tumors: Interaction of Neighborhood Social Determinants of Health and Neurological Risk

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Background This study investigated how neighborhood‐level social determinants of health (SDOH), including redlining and neurological risk, interact to influence cognitive outcomes in children treated for brain tumors (CTBT). Methods A retrospective chart review of 161 CTBT aged 5–17 was conducted.
Alannah R. Srsich, Manali Zope, Peter M. Fantozzi, Cassie N. Kline, Iris Paltin, Matthew C. Hocking   +5 more
wiley   +1 more source

Expression of TERRA in Different Grades of Astrocytoma

مجله دانشکده پزشکی اصفهان, 2015
Background: Brain tumors include burden of mortality from cancers. High grades of brain tumors are more aggressive and have poor prognosis. Introduction telomeres are the ends of linear chromosomes that serve as a protective cap to avoid permanent ...
Sepideh Dashti, Saeideh Ashouri, Majid Kheirollahi   +2 more
doaj  

SOX10 distinguishes oligodendrogliomas from low‐grade glioneuronal tumors/low‐grade gliomas with oligodendrocyte‐like features

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Oligodendrogliomas exhibit significant morphological overlap with low‐grade glioneuronal tumors/low‐grade gliomas with oligodendrocyte‐like features, posing challenges in histopathological diagnosis. SOX10, a transcription factor critical for oligodendrocyte maturation and central nervous system myelination, may serve as a diagnostic marker ...
Danmei Zhou, Xiaomu Hu, Yin Wang, Feng Tang, Zunguo Du, Ji Xiong   +5 more
wiley   +1 more source