Results 111 to 120 of about 46,157 (226)

Tumor‐type–specific expression of TTF‐1 in primary central nervous system tumors classified by the 2021 WHO criteria

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Thyroid transcription factor‐1 (TTF‐1) is a widely used immunohistochemical marker for tumors of thyroid and pulmonary origin; however, its expression profile and diagnostic relevance in primary central nervous system (CNS) tumors remain incompletely characterized, particularly following the revisions in the 2021 WHO Classification of CNS ...
Lu Xu, Hong‐Jiu Ren, Jian Gu, Bing‐Wen Shan, Tong Ren, Chu‐Hang Liu, Chun‐Xian Cai, Xiao‐Yu Zhang, Juan‐Han Yu   +8 more
wiley   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Spinal Cord Schistosomiasis: A Rare and Severe Presentation of a Common Disease—A Case Report and Review of Literature

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Spinal cord schistosomiasis (SCS) is a rare but potentially disabling manifestation of Schistosoma mansoni infection caused by ectopic deposition of parasite eggs within the spinal cord via Batson's vertebral venous plexus, resulting in granulomatous inflammation and neurological injury.
Elham Sany Shemsu, Thomas Asfaw Atnafu, Eskedar Ferdu Azerefegne, Ilili Amin Aliye   +3 more
wiley   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source

Accelerating Pediatric Oncology Drug Development: Advances in Clinical Pharmacology, Trial Design, Non‐Clinical Evidence, and Regulatory Science

The Journal of Clinical Pharmacology, Volume 66, Issue 7, July 2026.
Abstract Pediatric oncology drug development remains uniquely challenging due to the rarity and biological heterogeneity of childhood cancers, ethical considerations in trial conduct, and the limited feasibility of large, randomized studies. Despite these barriers, recent years have seen a notable acceleration in the approval of oncology therapies for ...
Ya‐Feng Wen, Xiaoning Wang, Sarandeep Boyanapalli, Lee Anderson, Thao Dang, Guan Xing, Marianna Calvet, Tiffany Hart, Sreeneeranj Kasichayanula, Xiaochen Zhao   +9 more
wiley   +1 more source

A Comparative Study of IVIM‐MRI Fitting Techniques in Glioma Grading: Conventional, Bayesian, and Voxel‐Wise and Spatially‐Aware Deep Learning Approaches

Journal of Magnetic Resonance Imaging, Volume 64, Issue 1, Page 184-200, July 2026.
ABSTRACT Background Intravoxel incoherent motion (IVIM) analysis of diffusion‐weighted MRI (DWI) provides microvascular perfusion and diffusion information. However, parameter estimation is limited by noise sensitivity, variability across fitting methods, and lack of standardization.
Misha P. T. Kaandorp, Andras Jakab, Christian Federau, Peter T. While   +3 more
wiley   +1 more source

Clinically Feasible White Matter Fiber Tractography in Peritumoral Zones With Cerebral Vasogenic Edema

Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 287-301, July 2026.
ABSTRACT Purpose In diffusion MRI, vasogenic edema manifests as a major fraction of isotropic water that dilutes the anisotropic intra‐axonal portion of the signal. Many tractography algorithms mistake vasogenic edema for the white matter boundary and terminate tracking to prevent producing spurious streamlines.
Patryk Filipiak, Timothy M. Shepherd, Kamri Clarke, Gaia Ressa, Dimitris G. Placantonakis, Fernando E. Boada, Steven H. Baete   +6 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Desired Support and Design Preferences for a Supported Self‐Management Intervention for People With Lower‐Grade Gliomas: Co‐Design Findings From the Ways Ahead Project

Psycho-Oncology, Volume 35, Issue 7, July 2026.
ABSTRACT Background Lower‐grade gliomas (LGG) are a subgroup of primary brain tumours. People with LGG often live long‐term with wide‐ranging symptoms and impairments (e.g., seizures, cognitive impairment) and uncertainty about their disease progression.
Ben Rimmer, Sophie Williams, Joanne Lewis, Lizzie Dutton, Richéal Burns, Pamela Gallagher, Vera Araújo‐Soares, Tracy Finch, Linda Sharp   +8 more
wiley   +1 more source

Prenatal diagnosis of cardiac rhabdomyoma: implications for predicting tuberous sclerosis complex and guiding perinatal management

Ultrasound in Obstetrics &Gynecology, Volume 68, Issue 1, Page 88-98, July 2026.
ABSTRACT Objective To identify prenatal predictors of tuberous sclerosis complex (TSC) in fetuses with one or more cardiac rhabdomyomas (CR), evaluate an integrated multimodal diagnostic workflow using fetal magnetic resonance imaging (MRI) and trio whole‐exome sequencing (trio‐WES) and characterize perinatal outcomes.
X. Cai, J. Liu, W. Zheng, Y. Jiao, Y. Lou, M. Deng, W. Zhao, K. Yan, L. Sun   +8 more
wiley   +1 more source