Results 131 to 140 of about 75,763 (246)

Precision Oncology for Pediatric Solid Tumors Using In‐Hospital Pediatric/AYA Malignancy‐Specific Panel Sequencing

Cancer Science, Volume 117, Issue 3, Page 797-806, March 2026.
Our findings indicate that a pediatric/AYA‐specific targeted panel deployed in a hospital can deliver rapid, clinically actionable molecular insights with high diagnostic and prognostic yield. This complements larger sequencing platforms by offering speed, focused content, and easier interpretation.
Masato Kojima, Sho Kurihara, Isamu Saeki, Ryo Touge, Keigo Nakashima, Shuhei Karakawa, Fumiyuki Yamasaki, Satoshi Okada, Eiso Hiyama   +8 more
wiley   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

AI‐Based Methods in Neuropathology for Diagnosis and Treatment of Brain Tumors

European Journal of Neurology, Volume 33, Issue 3, March 2026.
ABSTRACT Background Artificial Intelligence (AI) is rapidly emerging as a transformative tool in medical research and practice. In neuro‐oncology, AI may help to enhance diagnostic accuracy and reproducibility, manage complex multi‐modal data, and facilitate personalized treatment.
Thomas Roetzer‐Pejrimovsky, Nicole Amberg, Georg Widhalm, Romana Höftberger   +3 more
wiley   +1 more source

Pediatric Investigation Plans for seizure and epilepsy treatments: An analysis since the implementation of the European Pediatric Regulation in 2006

Epilepsia, Volume 67, Issue 3, Page 1267-1283, March 2026.
Abstract Objective A Pediatric Investigation Plan (PIP) implemented under the European Pediatric Regulation (EC No. 1901/2006) aims to ensure early and systematic evaluation of medicines for children. We analyze PIPs for antiseizure medications (ASMs) submitted to the European Medicines Agency (EMA) since 2006, characterizing their content, focusing on
Valeria Agostini, Stéphane Auvin
wiley   +1 more source

Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone‐Mediated Autophagy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Calcium dysregulation is closely associated with cancer cell proliferation, migration, and invasion. Transient receptor potential canonical 1 (TRPC1) plays an essential role in regulating calcium homeostasis. However, the role of TRPC1 in calcium dysregulation in gliomas remains incompletely understood. In this study, we demonstrate that TRPC1
Jialong Chen, Yixi Lai, Mingque Li, ZiWei Cai, Renjian Lu, Linhua Liu, Yongming Peng, Chunlai Fu, Zhefan Xie, Xueqion Zhou, Jiaxian Liu, He Zhang   +11 more
wiley   +1 more source

High-Grade Astrocytoma With Piloid Features: An Aggressive Clinicogenomic Entity Distinct From Pilocytic Astrocytoma. [PDF]

J Korean Med Sci
Kang J, Kim EE, Lee K, Kim SI, Park JW, Won JK, Phi JH, Kim SK, Park CK, Lee H, Park SH.   +10 more
europepmc   +1 more source

Survival trends of grade I, II, and III astrocytoma patients and associated clinical practice patterns between 1999 and 2010: A SEER-based analysis.

Neuro-Oncology Practice, 2016
Xuezhi Dong, A. Noorbakhsh, B. Hirshman, Tianzan Zhou, Jessica A. Tang, D. Chang, B. Carter, Clark C. Chen   +7 more
semanticscholar   +1 more source

Multicystic Kidney Disease in a Family With Tuberous Sclerosis Complex

Nephrology, Volume 31, Issue 3, March 2026.
ABSTRACT Tuberous sclerosis complex (TSC) is a multisystem condition associated with disease‐causing variants of either TSC1 or TSC2 genes. Significant kidney involvement in TSC is most often due to development of angiomyolipomas (AMLs) and occurs more frequently in people with TSC2 variants.
Julia S. Donald, Caitlin Edmonstone, Denise L. Chan, Clara W. T. Chung, Sean E. Kennedy   +4 more
wiley   +1 more source

T2-FLAIR mismatch sign in nonenhancing astrocytoma, IDH-mutant: impact of tumor area on diagnostic sensitivity. [PDF]

J Neurooncol
Ozono I, Yamasaki F, Onishi S, Yonezawa U, Taguchi A, Takeishi Y, Khairunnisa NI, Amatya VJ, Takeshima Y, Horie N.   +9 more
europepmc   +1 more source

Frizzled‐9 Expression Is Associated With Aggressive Clinicopathological Features and Reduced Overall Survival in Invasive Breast Carcinoma

Pathology International, Volume 76, Issue 3, March 2026.
Graphical summary illustrating the evaluation of FZD9 in breast cancer. FZD9 protein expression was assessed by immunohistochemistry in 81 breast tumor samples and further investigated in breast cancer cell lines exposed to cytotoxic and epigenetic treatments. Higher FZD9 expression was associated with aggressive clinicopathological features and poorer
Daniel Rodrigues de Bastos, Ricardo Cesar Cintra, Adhemar Longatto‐Filho, Lara Termini   +3 more
wiley   +1 more source