Results 61 to 70 of about 1,482,446 (314)

Photoinduced Copper-Catalyzed Asymmetric C-O Cross-Coupling.

Journal of the American Chemical Society, 2021
The construction of carbon-heteroatom bonds is one of the most active areas of research in organic chemistry because the function of organic molecules is often derived from the presence of heteroatoms.
Jun Chen, Yufan Liang, Peng-Zi Wang, Guo-qing Li, Bin Zhang, Hao-Dong Qian, Xiao-Die Huan, W. Guan, W. Xiao, Jia‐Rong Chen   +9 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Asymmetric optical transmission based on unidirectional excitation of surface plasmon polaritons in gradient metasurface.

Optics Express, 2017
Asymmetric optical transmission is fundamental and highly desirable in information processing and full manipulation of lightwave. We here propose an asymmetric optical transmission device consisting of a gradient metasurface and a one-dimensional ...
Yonghong Ling, Lirong Huang, W. Hong, Tongjun Liu, Yali Sun, Jing Luan, G. Yuan   +6 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Approximation of the Statistical Characteristics of Piecewise Linear Systems with Asymmetric Damping and Stiffness under Stationary Random Excitation

Mathematics, 2022
In this paper, the dynamic response of piecewise linear systems with asymmetric damping and stiffness for random excitation is studied. In order to approximate the statistical characteristics for each significant output of piecewise linear system, a ...
Tudor Sireteanu, Ana-Maria Mitu, Ovidiu Solomon, Marius Giuclea   +3 more
doaj   +1 more source

Steady state entanglement of two coupled qubits

, 2010
The maximum entanglement between two coupled qubits in the steady state under two independent incoherent sources of excitation is reported. Asymmetric configurations where one qubit is excited while the other one dissipates the excitation are optimal for
An, Angelakis, Ashhab, Bayer, Benatti, Benatti, Benson, Bloch, Braun, Briegel, Campbell, Clark, Clarke, Contreras-Pulido, del Valle, del Valle, del Valle, Elena del Valle, Ficek, Ficek, Gallardo, Gerardot, Hao, Hartmann, Hartmann, Hor-Meyll, Horodecki, Huang, Huelga, Imamoglu, Jakóbczyk, Jakóbczyk, Kim, Krenner, Ladd, Lambert, Laucht, Laussy, Li, Majer, Munro, Osnaghi, Plenio, Rivas, Schneider, Shan, Steffen, Verstraete, Wang, Wootters, Xiang-Ping, Xu, Yi, Yu, Zheng, Zhou   +55 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Theory of nucleon transfer in the dynamical two-center shell model [PDF]

, 2006
The theory of nucleon transfer in heavy ion reactions is formulated on the basis of the molecular particlecore model for a system consisting of two cores and one extracore nucleon. The extracore nucleon is described by the molecular wave functions of the
Greiner, Walter, Park, Jae Young, Scheid, Werner   +2 more
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source